Anti-diabetic and anti-cholesterolemic activity of methanol extracts of three species of Amaranthus

查看全文 作　　者：Girija [1]K;Lakshman [1]K;Udaya [1]Chandrika;Sabhya Sachi [1]Ghosh;Divya [1]T

机构地区：[1]Department of Pharmacognosy,PES College of Pharmacy

出　　处：《Asian Pacific Journal of Tropical Biomedicine》索引2011年第1卷第2期,共6页

摘　　要：Objective:To investigate the anti-diabetic and anti-cholesterolemic activity of methanol extracts of leaves of Amaranthus caudatus,Amaranthus spinosus and Amaranthus viridis in normal and streptozotocin(STZ) induced diabetic rats.Methods:In this study,the anti-diabetic and anti-cholesterolemic activity of methanol extracts of leaves of all three plants was evaluated by using normal and STZ induced diabetic rots at a dose of 200 mg/kg and 400 mg/kg p.o.daily for 21 days.Blood glucose levels and body weight were monitored at specific intervals,and different biochemical parameters,serum cholesterol,serum triglyceride,high density lipoprotein, low density lipoprotein and very low density lipoprotein were also assessed in the experimental animals.Histology of pancreas was performed.Results:It was found that all the three plants at 400 mg/kg dose showed significant anti-diabetic and anti-cholesterolemic activity(P<0.01),while at 200 mg/kg dose less significant anti-diabetic activity(P<0.05) was observed.Concluslons: Methanol extracts of Amaranthus caudatus,Amaranlhus spinosus and Amaranthus viridis showed significant anti-diabetic and anti-cholesterolemic activity,which provides the scientific proof for their traditional claims. 关键词：AMARANTHUS caudatus AMARANTHUS spinosus AMARANTHUS VIRIDIS ANTI-DIABETIC ACTIVITY Anti-cholesterolemic ACTIVITY Methanol extract BIOCHEMICAL parameter

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Anti-diabetic and anti-cholesterolemic activity of methanol extracts of three species of Amaranthus

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