Synthesis of an AIE-active fluorogen and its application in cell imaging

查看全文 作　　者：LAM Jacky Wing [1]Yip;FAISAL [1]Mahtab;NG Ka [2]Ming;LUO Kathy [2,3]Qian

机构地区：[1]Department of Chemistry, The Hong Kong University of Science & Technology (HKUST), Clear Water Bay;[2]Department of Chemical and Biomolecular Engineering, HKUST, Clear Water Bay;[3]Bioengineering Graduate Program, HKUST, Clear Water Bay

出　　处：《Science China Chemistry》索引2009年第52卷第1期,共5页

基　　金：Supported by the Research Grants Council of Hong Kong (Grant Nos. 603008, 601608 and 602707);the National Natural Science Foundation of China (Grant No. 20634020);the CAO GuangBiao Foundation of Zhejiang University 摘　　要：A fluorogen named 1-decyl-1-methyl-2,5-bis{4-[(N,N-diethylamino)methyl]phenyl}-3,4-diphenylsilole (3) was synthesized. It emitted weakly as isolated molecule but strongly as supramolecular aggregate, showing a characteristic behavior of aggregation-induced emission (AIE). The molecules of 3 formed highly emissive nanoparticles in aqueous media, which quickly and selectively marked cytoplasm of HeLa cells and posed no toxicity to the living cells. The fluorogen is thus a promising candidate mate-rial for cell imaging as a sensitive, selective and cytocompatible biosensor. 关键词：aggregation-induced EMISSION BIOSENSOR CELL IMAGING

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Synthesis of an AIE-active fluorogen and its application in cell imaging

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