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Differential changes in intrinsic innervation and interstitial cells of Cajal in small bowel atresia in newborns

查看全文 作　　者：Stefan [1]Gfroerer;Roman [2]Metzger;Henning [1]Fiegel;Priya [3]Ramachandran;Udo [1]Rolle 高影响力作者 机构地区：[1]Department of Paediatric Surgery,Johann Wolfgang Goethe-University Frankfurt/M,Theodor-Stern-Kai 7,60590 Frankfurt/M,Germany;[2]Department of Paediatric Surgery,University of Leipzig,04103 Leipzig,Germany;[3]Department of Pediatric Surgery,Kanchi Kamakoti Childs Trust Hospital,12-A Chennai,India高影响力机构 出　　处：《World Journal of Gastroenterology》索引2010年第16卷第45期,共6页高影响力期刊 摘　　要：AIM: To investigate morphological changes of the enteric nervous system (ENS) and the interstitial cells of Cajal (ICCs) in small bowel atresia.METHODS: Resected small bowel specimens from affected patients (n = 7) were divided into three parts (proximal, atretic, distal). Standard histology and enzyme immunohistochemistry anti-S100, anti-protein gene product (PGP) 9.5, anti-neurofilament (NF), antic-kit-receptor (CD117) was carried out on conventional paraffin sections of the proximal and distal part. RESULTS: The neuronal and glial markers (PGP 9.5, NF, S-100) were expressed in hypertrophied ganglia and nerve fibres within the myenteric and submucosal plexuses. Furthermore, the submucous plexus contained typical giant ganglia. The innervation pattern of the proximal bowel resembled intestinal neuronal dysplasia. The density of myenteric ICCs was clearly reduced in the proximal bowel, whereas a moderate number of muscular ICCs were found. The anti-CD117 immunore- action revealed additional numerous mast cells. The distal bowel demonstrated normal morphology and density of the ENS, the ICCs and the mast cells.CONCLUSION: The proximal and distal bowel in small bowel atresia revealed clear changes in morphology and density of the ENS and ICCs. 关 键 词：Small bowel ATRESIA ENTERIC nervous system Gastrointestinal motility Interstitial cells of CAJAL
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