PPIs are not associated with a lower incidence of portal-hypertension-related bleeding in cirrhosis

查看全文 作　　者：Mauricio Garcia-Saenz-de-[1]Sicilia;Francisco Sanchez-[1]Avila;Norberto C Chavez-[2]Tapia;Gustavo Lopez-[3]Arce;Sandra Garcia-[2]Osogobio;Roberto Ruiz-[1]Cordero;Felix I Tellez-[3]Avila

机构地区：[1]Department of Gastroenterology,Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubiran,Mexico City,Mexico;[2]Medica Sur Clinic and Fundation;[3]Endoscopy Department,Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran,Mexico City,14000,Mexico

出　　处：《World Journal of Gastroenterology》索引2010年第16卷第46期,共5页

摘　　要：AIM:To determine if proton pump inhibitor use in cirrhotic patients with endoscopic findings of portal hypertension is associated with a lower frequency of gastrointestinal bleeding.METHODS:Patients with cirrhosis and endoscopic findings related to portal hypertension,receiving or not receiving proton pump inhibitor (PPI) therapy,were included retrospectively.We assigned patients to two groups:group 1 patients underwent PPI therapy and group 2 patients did not undergo PPI therapy.RESULTS:One hundred and five patients with a median age of 58 (26-87) years were included,57 (54.3%) of which were women.Esophageal varices were found in 82 (78%) patients,portal hypertensive gastropathy in 72 (68.6%) patients,and gastric varices in 15 (14.3%) patients.PPI therapy was used in 45.5% of patients (n=48).Seventeen (16.1%) patients presented with upper gastrointestinal bleeding;in 14/17 (82.3%) patients,bleeding was secondary to esophageal varices,and in 3/17 patients bleeding was attributed to portal hypertensive gastropathy.Bleeding related to portal hypertension according to PPI therapy occurred in 18.7% (n=9) of group 1 and in 14% (n=8) of group 2 (odds ratio:0.83,95% confidence interval:0.5-1.3,P=0.51).CONCLUSION:Portal hypertension bleeding is not associated with PPI use.These findings do not support the prescription of PPIs in patients with chronic liver disease with no currently accepted indication. 关键词：Drug prescription Liver CIRRHOSIS PORTAL HYPERTENSION Proton pump inhibitors Upper GASTROINTESTINAL BLEEDING

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PPIs are not associated with a lower incidence of portal-hypertension-related bleeding in cirrhosis

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