Predictors of loss of hepatitis B surface antigen in HIV-infected patients

查看全文 作　　者：George [1]Psevdos;Jong Hun [2]Kim;Jin S [1]Suh;Victoria Lee [3]Sharp 机构地区：[1]Center for Comprehensive Care,Division of Infectious Diseases,St.Luke's-Roosevelt Hospital Center;[2]Division of Infectious Diseases,University of Pittsburgh Medical Center;[3]Center for Comprehensive Care,St.Luke's-Roosevelt Hospital Center 出　　处：《World Journal of Gastroenterology》索引2010年第16卷第9期,共4页 摘　　要：AIM:To study factors associated with loss of hepatitis B surface antigen (HBsAg) in patients co-infected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV).METHODS:We retrospectively reviewed the medical records of 5681 patients followed up at two New York City HIV clinics from January 1999 to May 2007.Clinical and laboratory parameters including baseline and follow-up HIV viral loads,CD4 cell counts,alanine transaminase levels,demographics,presence of hepatitis C infection,and treatment with highly active antiretroviral therapy dually active against both HIV and HBV infection,were analyzed to determine factors associated with loss of HBsAg.RESULTS:Three hundred and fifty five patients (355/5681,6.84%) were co-infected with HIV and HBV and were evaluated.Of these,226 patients with more than 12 mo follow-up were included in further analysis to determine factors associated with loss of HBsAg in the long-term follow-up.In the univariate analysis,baseline CD4 cell count was associated with loss of HBsAg (P=0.052).Cox regression analysis revealed that loss of HBsAg was associated with baseline CD4 cell count > 500 cells/mm3 (P=0.016,odds ratio:76.174,95% confidence interval:2.233-2598.481).CONCLUSION:Our study showed an interesting association of loss of HBsAg in HIV-HBV co-infected patients with higher CD4 cell count,suggesting that T-cell cytolytic activity against HBV may still be effective in clearing HBV infection. 关 键 词：Human IMMUNODEFICIENCY VIRUS HEPATITIS B VIRAL ANTIGENS Surface ANTIGENS