Study for the Gating Kinetics of Potassium Channel in Clonal Pheochromocytoma Cells Based On Fractal Model

查看全文 作　　者：LIU Xiang ming 1, TAO Min 1, HAN Xiao dong 1, FAN Jing 2, LIN Jia yui 1 1 School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China 2 Department of Physiology, Sun Yat Sen University of Medical

出　　处：《Chinese Journal of Biomedical Engineering(English Edition)》索引2000年第9卷第4期,共10页

基　　金：It is supported by the National Natural science Foundation of China(No.3 9170 2 2 2 ) 摘　　要：To study the gating kinetics of voltage dependent K + channel in clonal pheochromocytoma (PC12) cells, the inward currents of K channel in PC12 cells were recorded using cell attached patch clamp technique. The fractal features of the open and closed time distributions were determined. The fractal dimensions and kinetic setpoints for the open and closed durations were estimated. It was found that the fractal dimension D was independent of voltage and the logarithm logA of the setpoint A was inversely proportional to the pipette potential (Vp) for the closed durations. While for the open durations the fractal dimension D was inversely proportional to the pipette potential and the logarithm logA of the setpoint A was independent of voltage. Thus, for this channel the open and closed durations and voltage dependence of the gating could be well described by the fractal model. 关键词：PC12 cells POTASSIUM ion channels FRACTAL model FRACTAL dimension kinetic setpoint

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Study for the Gating Kinetics of Potassium Channel in Clonal Pheochromocytoma Cells Based On Fractal Model

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