Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature

查看全文 作　　者：Patricia [1]Sarlos;Erzsebet [2,3]Kovesdi;Lili [2,3]Magyari;Zsolt [2,3]Banfai;Andras [2,3]Szabo;Andras [4]Javorhazy;Bela [2,3]Melegh

机构地区：[1]1st Department of Internal Medicine, University of Pecs;[2]Department of Medical Genetics, University of Pecs;[3]Szentagothai Research Centre;[4]Department of Urology, University of Pecs

出　　处：《World Journal of Gastrointestinal Pathophysiology》索引2014年第5卷第3期,共18页

基　　金：Supported by The grant of the Hungarian Science Foundation,No.OTKA K103983 摘　　要：Ulcerative colitis(UC) is one of the main types of inflammatory bowel disease, which is caused by dysregulated immune responses in genetically predisposed individuals. Several genetic factors, including interleukin and interleukin receptor gene polymorphisms and other inflammation-related genes play central role in mediating and modulating the inflammation in the human body, thereby these can be the main cause of development of the disease. It is clear these data are very important for understanding the base of the disease, especially in terms of clinical utility and validity, but summarized literature is exiguous for challenge health specialist that can used in the clinical practice nowadays. This review summarizes the current literature on inflammationrelated genetic polymorphisms which are associated with UC. We performed an electronic search of Pubmed Database among publications of the last 10 years, using the following medical subject heading terms: UC, ulcerative colitis, inflammation, genes, polymorphisms, and susceptibility. 关键词：ULCERATIVE COLITIS Inflammatory factors Genes POLYMORPHISMS SUSCEPTIBILITY

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Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature

参考文献(20)

引证文献(15)

耦合文献(70)

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