Endothelial progenitor cells in cardiovascular diseases

查看全文 作　　者：Poay Sian Sabrina [1,2]Lee;Kian Keong [1,2]Poh 机构地区：[1]Cardiac DepartmentNational University Heart Centre, National University HealthSystem, Singapore;[2]Yong Loo Lin School of Medicine, Na-tional University of Singapore 出　　处：《World Journal of Stem Cells》索引2014年第6卷第3期,共12页 基　　金：Supported by The National Medical Research Council,Singa-pore,No.NMRC/NIG/1038/2010;the National University Health System Clinician Scientist Program(NCSP)from the Cli-nician Scientist Unit,Yong Loo Lin School of Medicine,National University of Singapore 摘　　要：Endothelial dysfunction has been associated with the development of atherosclerosis and cardiovascular diseases. Adult endothelial progenitor cells(EPCs) are derived from hematopoietic stem cells and are capable of forming new blood vessels through a process of vas-culogenesis. There are studies which report correlations between circulating EPCs and cardiovascular risk fac-tors. There are also studies on how pharmacotherapies may influence levels of circulating EPCs. In this review, we discuss the potential role of endothelial progenitor cells as both diagnostic and prognostic biomarkers. In addition, we look at the interaction between cardio-vascular pharmacotherapies and endothelial progenitor cells. We also discuss how EPCs can be used directly and indirectly as a therapeutic agent. Finally, we evalu-ate the challenges facing EPC research and how these may be overcome. 关 键 词：ENDOTHELIAL PROGENITOR cells Cardiovasculardiseases HYPERTENSION Diabetes DYSLIPIDEMIA Therapy STENTS