Extra-intestinal and long term consequences of Giardia duodenalis infections

查看全文 作　　者：Marie CM [1,2,3]Halliez;André G [1]Buret

机构地区：[1]Department of Biological Sciences,Inflammation Research Network,University of Calgary,Calgary,Alberta,AB T2N 1N4,Canada;[2]Parasitology Department,Rouen University Hospital & EA 3800;[3]Institute for Biomedical & Research,University of Rouen,Rouen,76183,France

出　　处：《World Journal of Gastroenterology》索引2013年第19卷第47期,共12页

基　　金：Supported by Grants from the Natural Sciences and Engineering Research Council of Canada(individual operating and CREATE),the France-Canada Research Fund;the'Ministère de l’enseignement supérieur et de la recherche',French Ministry of Secondary Education and Research 摘　　要：Giardiasis is the most common waterborne parasitic infection of the human intestine worldwide.The etiological agent,Giardia duodenalis(syn.G.intestinalis,G.lamblia),is a flagellated,binucleated protozoan parasite which infects a wide array of mammalian hosts.Human giardiasis is a true cosmopolitan pathogen,with highest prevalence in developing countries.Giardiasis can present with a broad range of clinical manifestations from asymptomatic,to acute or chronic diarrheal disease associated with abdominal pain and nausea.Most infections are self-limiting,although re-infection and chronic infection can occur.Recent evidence indicating that Giardia may cause chronic post-infectious gastrointestinal complications have made it a topic of intense research.The causes of the post-infectious clinical manifestations due to Giardia,even after complete elimination of the parasite,remain obscure.This review offers a state-of-the-art discussion on the long-term consequences of Giardia infections,from extra-intestinal manifestations,growth and cognitive deficiencies,to post-infectious irritable bowel syndrome.The discussion also sheds light on some of the novel mechanisms recently implicated in the production of these postinfectious manifestations. 关键词：GIARDIASIS Inflammatory disorders Extraintestinal MANIFESTATIONS of ENTERITIS Failure to thrive Post-infectious IRRITABLE bowel syndrome

相关文献

参考文献（127）
引证文献（10）
耦合文献（23）

参考文献(127)

引证文献(10)

耦合文献(23)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Extra-intestinal and long term consequences of Giardia duodenalis infections

参考文献(127)

引证文献(10)

耦合文献(23)

用户提示