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Non-microbial approach for Helicobacter pylori as faster track to prevent gastric cancer than simple eradication

查看全文 作　　者：Sang-Ho [1]Park;Napapan [1]Kangwan;Jong-Min [1]Park;Eun-Hee [1]Kim;Ki Baik [1]Hahm 高影响力作者 机构地区：[1]CHA Cancer Prevention Research Center,CHA Cancer Institute,CHA University,Seoul 135-081,South Korea高影响力机构 出　　处：《World Journal of Gastroenterology》索引2013年第19卷第47期,共10页高影响力期刊 基　　金：Supported by A Grant from the Ministry of Education and Science Technology,No.2009-0081758,South Korea 摘　　要：Although the International Agency for Research on Cancer declared Helicobacter pylori(H.pylori)as a definite human carcinogen in 1994,the Japanese Society for Helicobacter Research only recently(February 2013)adopted the position that H.pylori infection should be considered as an indication for either amelioration of chronic gastritis or for decreasing gastric cancer mortality.Japanese researchers have found that H.pylori eradication halts progressive mucosal damage and that successful eradication in patients with non-atrophic gastritis most likely prevents subsequent development of gastric cancer.However,those who have already developed atrophic gastritis/gastric atrophy retain potential risk factors for gastric cancer.Because chronic perpetuated progression of H.pylori-associated gastric inflammation is associated with increased morbidity culminating in gastric carcinogenesis,a non-microbial approach to treatment that provides long-term control of gastric inflammation through nutrients and other interventions may be an effective way to decrease this morbidity.This non-microbial approach might represent a new form of prerequisite'rescue'therapy that provides a quicker path to the prevention of gastric cancer as compared to simple eradication. 关 键 词：Helicobacter pylori Gastric cancer Prevention ATROPHIC GASTRITIS Non-microbial APPROACH
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