Helicobacter pylori eradication and reflux disease onset:Did gastric acid get 'crazy'?

查看全文 作　　者：Angelo [1]Zullo;Cesare [1]Hassan;Alessandro [2]Repici;Vincenzo [1]Bruzzese

机构地区：[1]Gastroenterology and Digestive Endoscopy Unit,Nuovo Regina Margherita Hospital;[2]Digestive Endoscopy Unit,IRCCS Istituto Clinico Humanitas

出　　处：《World Journal of Gastroenterology》索引2013年第19卷第6期,共4页

摘　　要：Gastroesophageal reflux disease (GORD) is highly prevalent in the general population.In the last decade,a potential relationship between Helicobacter pylori (H.pylori) eradication and GORD onset has been claimed.The main putative mechanism is the gastric acid hypersecretion that develops after bacterial cure in those patients with corpus-predominant gastritis.We performed a critical reappraisal of the intricate pathogenesis and clinical data available in this field.Oesophagitis onset after H.pylori eradication in duodenal ulcer patients has been ascribed to a gastric acid hypersecretion,which could develop following body gastritis healing.However,the absence of an acid hypersecretive status in these patients is documented by both pathophysiology and clinical studies.Indeed,duodenal ulcer recurrence is virtually abolished followingH.pylori eradication.In addition,intra-oesophageal pH recording studies failed to demonstrated increased acid reflux following bacterial eradication.Moreover,oesophageal manometric studies suggest that H.pylori eradication would reduce-rather than favor-acid reflux into the oesophagus.Finally,data of clinical studies would suggest that H.pylori eradication is not significantly associated with eitherreflux symptoms or erosive oesophagitis onset,some data suggesting also an advantage in curing the infection when oesophagitis is already present.Therefore,the legend of 'crazy acid' remains-as all the others a fascinating,but imaginary tale. 关键词：HELICOBACTER pylori OESOPHAGEAL REFLUX OESOPHAGITIS ERADICATION PATHOPHYSIOLOGY Clinical studies

相关文献

参考文献（25）
引证文献（4）
耦合文献（38）

参考文献(25)

引证文献(4)

耦合文献(38)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Helicobacter pylori eradication and reflux disease onset:Did gastric acid get 'crazy'?

参考文献(25)

引证文献(4)

耦合文献(38)

用户提示