Gastric adenocarcinoma arising in gastritis cystica profunda presenting with selective loss of KCNE2 expression

查看全文 作　　者：Natsumi [1]Kuwahara;Riko [1]Kitazawa;Koto [1]Fujiishi;Yusa [1]Nagai;Ryuma [1]Haraguchi;Sohei [1]Kitazawa

机构地区：[1]Department of Molecular Pathology,Ehime University,Graduate School of Medicine,Ehime 791-0295,Japan

出　　处：《World Journal of Gastroenterology》索引2013年第19卷第8期,共4页

基　　金：Supported by The Grant-in-Aid from Ministry of Education, Culture,Sports,Science and Technology,Japan 摘　　要：Gastritis cystica profunda(GCP) is a rare condition caused by ectopic entrapment of gastric glands,probably secondary to the disruption of muscularis mucosae.GCP is often associated with gastric adenocarcinoma,and loss of the KCNE2 subunit from potassium channel complexes is considered a common primary target molecule leads to both GCP and malignancy.In this study,we,for the first time,analyzed the expression of KCNE2 in surgically excised tissue from human gastric cancer associated with GCP and confirmed that reduced KCNE2 expression correlates with disease formation. 关键词：KCNE2 GASTRITIS cystica profunda IMMUNOHISTOCHEMISTRY

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Gastric adenocarcinoma arising in gastritis cystica profunda presenting with selective loss of KCNE2 expression

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