Mechanobiology:A new frontier for human pluripotent stem cells

查看全文 作　　者：Jianping [1]Fu;Yubing [1]Sun;Koh Meng Aw [1]Yong 机构地区：[1]Integrated Biosystems and Biomechanics Laboratory,Department of Mechanical Engineering,Department of Biomedical Engineering,University of Michigan 出　　处：《医用生物力学》索引2013年第28卷第S1期,共3页 基　　金：supported by the National Science Foundation(CMMI 1129611, CBET 1149401,and ECCS 1231826);the American Heart Association(12SDG12180025) 摘　　要：Our understanding of the molecular and cellular mechanisms that control self-renewal,pluripotency and differentiation of human pluripotent stem cells(hPSCs)and our progress toward harnessing the regenerative potential of these cells to treat human diseases are advancing at a rapid rate.Human pluripotent stem cells(hPSCs)include human embryonic stem cells(hESCs)and human induced pluripotent stem cells(hiPSCs).Their unique capacity for indefinite self-renewal(unlimited proliferation)in vitro coupled with their ability to differentiate into almost any cell type present in the adult body(pluripotency)provide a potentially 关 键 词：PLURIPOTENT EMBRYONIC DIFFERENTIATE RENEWAL potentially FRONTIER regenerative advancing toward innovative