Special AT-rich sequence-binding protein 1 promotes cell growth and metastasis in colorectal cancer

查看全文 作　　者：Xue-Feng [1]Fang;Zhi-Bo [2]Hou;Xin-Zheng [3]Dai;Cong [4]Chen;Jing [5]Ge;Hong [1]Shen;Xiao-Feng [1]Li;Li-Ke [2]Yu;Ying [1]Yuan

机构地区：[1]Department of Medical Oncology,SecondAffiliated Hospital,Zhejiang University College of Medicine;[2]First Department of Respiratory Medicine,Nanjing Chest Hospital;[3]Liver Transplantation Center,First Affiliated Hospital of Nanjing Medical University,Key Laboratory of Living Donor Liver Transplantation,Ministry of Public Health;[4]Department of Gynecology of Traditional Chinese Medicine,Jiangsu Provincial Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine;[5]Department of Endocrinology,Jiangsu Provincial Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine

出　　处：《World Journal of Gastroenterology》索引2013年第19卷第15期,共9页

基　　金：Supported by The National Natural Science Foundation of China, No. 81101580 摘　　要：AIM: To evaluate the expression of special AT-rich sequence-binding protein 1 (SATB1 ) gene in colorectal cancer and its role in colorectal cancer cell proliferation and invasion.METHODS: Immunohistochemistry was used to detect the protein expression of SATB1 in 30 colorectal cancer (CRC) tissue samples and pair-matched adjacent nontumor samples. Cell growth was investigated after enhancing expression of SATB1. Wound-healing assay and Transwell assay were used to investigate the impact of SATB1 on migratory and invasive abilities of SW480 cells in vitro . Nude mice that received subcutaneous implantation or lateral tail vein were used to study the effects of SATB1 on tumor growth or metastasis in vivo . RESULTS: SATB1 was over-expressed in CRC tissues and CRC cell lines. SATB1 promotes cell proliferation and cell cycle progression in CRC SW480 cells. SATB1 over-expression could promote cell growth in vivo . In addition, SATB1 could significantly raise the ability of cell migration and invasion in vitro and promote the ability of tumor metastasis in vivo . SATB1 could up-regulate matrix metalloproteases 2, 9, cyclin D1 and vimentin, meanwhile SATB1 could down-regulate E-cadherin in CRC. CONCLUSION: SATB1 acts as a potential growth and metastasis promoter in CRC. SATB1 may be useful as a therapeutic target for CRC. 关键词：SPECIAL AT-rich sequence-binding protein 1 COLORECTAL cancer Proliferation Migration INVASION

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Special AT-rich sequence-binding protein 1 promotes cell growth and metastasis in colorectal cancer

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