Lactic acidosis during telbivudine treatment for HBV: A case report and literature review

查看全文 作　　者：Jia-Lin [1]Jin;Piao [1,2]Hu;Jia-Hong [3]Lu;Su-Shan [3]Luo;Xiao-Yun [1]Huang;Xin-Hua [1]Weng;Ji-Ming [1]Zhang

机构地区：[1]Department of Infectious Diseases,Huashan Hospital,Fudan University;[2]Department of Infectious Diseases,Xiaoshan First People’s Hospital;[3]Department of Internal Neurology,Huashan Hospital,Fudan University

出　　处：《World Journal of Gastroenterology》索引2013年第19卷第33期,共6页

基　　金：Supported by National Natural Science Foundation of China;No.81071354 and 81271833;National '973’ ’Project;No.2012CB519001;National Science and Technology Major Project of China;No.2012ZX10002007-001-002;No.2013ZX10002001 摘　　要：All oral nucleoside analogues against hepatitis B virus,with an exception of telbivudine,have been reported causing lactic acidosis(LA).Here we report the first case of chronic hepatitis B developing severe refractory LA during telbivudine monotherapy.A 36-year-old man of Chinese origin received telbivudine antiviral treatment for chronic hepatitis B.After 11 mo of therapy,he developed anorexia,nausea,and vomiting with mild muscle weakness.The patient was found with elevated serum creatine phosphokinase up to 3683 U/L(upper limit of normal 170 U/L)and marked LA.LA did not resolve immediately following discontinuation of telbivudine.His condition began to improve after hemodialysis treatment for 16 times and usage of glucocorticosteroid.The patient fully recovered after 16 wk of treatment.This is the first documented case with severe LA caused by telbivudine monotherapy.Besides serum creatine phosphokinase,blood lactate level should also be closely monitored in patients receiving telbivudine. 关键词：LACTIC acidosis/hyperlactatemia TELBIVUDINE Hepatitis B virus NUCLEOSIDE ANALOGUE ADVERSE effects

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Lactic acidosis during telbivudine treatment for HBV: A case report and literature review

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