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Effect of ulinastatin combined rivaroxaban on deep vein thrombosis in major orthopedic surgery

查看全文 作　　者：Xi [1,2]Yu;Yi [2]Tian;Ka [2]Wang;Ying-Lin [2]Wang;Guo-Yi [1]Lv;Guo-Gang [2]Tian 高影响力作者 机构地区：[1]Department of Anesthesiology,2nd hospital of Tianjin Medical University;[2]Department of Anesthesiology,Central South University Xiangya School of Medicine Affiliated Haikou Hospital高影响力机构 出　　处：《Asian Pacific Journal of Tropical Medicine》索引2014年第7卷第11期,共4页高影响力期刊 基　　金：supported in part by Scientific Research Fund of Hainan Provincial Health Department(No.2010-83) 摘　　要：Objective:To explore the effect of ulinastatin(UTI) continuous infusion combined Rivaroxaban on the deep vein thrombosis in patients undergoing major orthopedic surgery.Methods:Forty-five patients undergoing major orthopedic surgery were randomly divided into three groups:ulinastatin continuous infusion(Uc) group,ulinastatin single injection(Us) group and control(C) group.All patients received patient-controlled intravenous analgesia(PCIA) after operation,and took Rivaroxaban 10 mg orally 12 hours after operation.Ulinastatin(5 000 U/kg)was given intravenously to both Uc and Us groups preoperatively.Group C was given isometric normal saline,group Uc was pumped UTI continuous intravenously at the end of surgery(10 000U/kg) to 48 hours through PCIA pump.The values of hematocrit(HCT),thrombomodulin(TM),Interleukin(IL-6),thrombin-antithrombin complex(TAT),D-Dimer(D-D) were normally tested before surgery(T1),at the end of the surgery(T2),12 hours(T3).24 hours(T4) and 48 hours(T5)after surgery.Results:Compared with T1,there was an upward tendency in TM,IL-6,TAT,and D-D after operation in group C group(P <0.05).The values of them were significandy increased from nearly 24-hour after surgery in Us group(P<0.05).In group Uc.there were no significant changes in these indices after operation(P>0.05).Conclusions:During the perioperative period,ulinastatin continuous infusion combined Rivaroxaban can correct blood hypercoagulability through different approaches in patients undergoing major orthopedic surgery. 关 键 词：ULINASTATIN RIVAROXABAN DVT ORTHOPEDIC SURGERY
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