Role of sphingosine 1-phosphate in anti-atherogenic actions of high-density lipoprotein

查看全文 作　　者：Koichi [1]Sato;Fumikazu [1]Okajima

机构地区：[1]Laboratory of Signal Transduction,Institute for Molecular and Cellular Regulation,Gunma University

出　　处：《World Journal of Biological Chemistry》索引2010年第1卷第11期,共11页

基　　金：Supported by Grants-in-Aid for scientific research from the Japan Society for the Promotion of Science,No.20015008,20054003,and 21390016 摘　　要：The reverse cholesterol transport mediated by highdensity lipoprotein(HDL)is an important mechanism for maintaining body cholesterol,and hence,the crucial anti-atherogenic action of the lipoprotein.Recent studies,however,have shown that HDL exerts a variety of anti-inflammatory and anti-atherogenic actions independently of cholesterol metabolism.The present review provides an overview of the roles of sphingosine 1-phosphate(S1P)/S1P receptor and apolipoprotein A-I/ scavenger receptor class B typeⅠsystems in the antiatherogenic HDL actions.In addition,the physiological significance of the existence of S1P in the HDL particles is discussed. 关键词：HIGH-DENSITY LIPOPROTEIN SPHINGOSINE 1-phosphate SCAVENGER receptor class B typeⅠ Antiatherogenic ACTIONS

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Role of sphingosine 1-phosphate in anti-atherogenic actions of high-density lipoprotein

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引证文献(4)

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