Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells

查看全文 作　　者：Cecile [1]CORBIERE;Bertrand [1]LIAGRE;Faraj [1]TERRO;Jean-Louis [1]BENEYTOUT

机构地区：[1]Laboratoire de Biochimie UPRES EA 1085,Faculté de Pharmacie,rue du Docteur Marcland,87025 Limoges Cedex,France,Laboratoire de Biochimie UPRES EA 1085,Faculté de Pharmacie,rue du Docteur Marcland,87025 Limoges Cedex,France,Service d'Histologie et Biologic Cellulaire Faculte de Medecine,rue du Docteur Marcland,87025 Limoges Cedex,France,Laboratoire de Biochimie UPRES EA 1085,Faculté de Pharmacie,rue du Docteur Marcland,87025 Limoges Cedex,France

出　　处：《Cell Research》索引2004年第14卷第3期,共9页

摘　　要：Previously, we demonstrated that a plant steroid, diosgenin, altered cell cycle distribution and induced apoptosis in the human osteosarcoma 1547 cell line. The objective of this study was to investigate if the antiproliferative effect of diosgenin was similar for different human cancer cell lines such as laryngocarcinoma HEp-2 and melanoma M4Beu cells. Moreover, this work essentially focused on the mitochondrial pathway. We found that diosgenin had an important and similar antiproliferative effect on different types of cancer cells. In addition, our new results show that diosgenininduced apoptosis is caspase-3 dependent with a fall of mitochondrial membrane potential, nuclear localization of AIF and poly (ADP-ribose) polymerase cleavage. Diosgenin treatment also induces p53 activation and cell cycle arrest in the different cell lines studied. 关键词：薯蓣皂苷配基细胞凋亡 P53 AIF 人类癌细胞细胞凋亡诱导因子

相关文献

参考文献（41）
引证文献（29）
耦合文献（0）

参考文献(41)

引证文献(29)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells

参考文献(41)

引证文献(29)

用户提示