Association of -238G/A polymorphism of tumor necrosis factor-alpha gene promoter region with outcomes of hepatitis B virus infection in Chinese Han population

查看全文 作　　者：Liang-[1]PingLu;Xing-[2]WangLi;[3]YingLiu;Guo-[4]ChangSun;Xue-[5]PingWang;Xi-[3]LinZhu;Quan-[4]YouHu;[1]HuiLi

机构地区：[1]DepartmentofEpidemiology,InstituteofBasicMedicalSciences,ChineseAcademyofMedicalSciences;SchoolofBasicMedicine,PekingUnionMedicalCollege,Beijing100005,China;[2]DepartmentofInternalMedicine,DitanHospital,Beijing100011,China;[3]NationalLaboratoryofMedicalMolecular.Biology,InstituteofBasicMedicalSciences,ChineseAcademyofMedicalSciences;SchoolofBasicMedicine,PekingUnionMedicalCollege,Beijing100005,China;[4]DepartmentofClimcalLaboratory,ShunyiDistrictHospital,Beijing101300,China;[5]DepartmentofClinicalLaboratory,DitanHospital,Beijing100011,China

出　　处：《World Journal of Gastroenterology》索引2004年第10卷第12期,共5页

基　　金：Supported by the Research Funit for the Doctoral Training Program from the Ministry of Education,No.2000002340 and Beijing Municipal Government Commission for Science & Technology,No.H020920020590 摘　　要：AIM: To clarify whether -238G/A polymorphism of tumor necrosis factor-a (TNF-a) gene promoter region was associated with outcomes of hepatitis B virus (HBV) infection in Han population of northern China, and to analyze the geneenvironment interaction between -238G/A polymorphism and cigarette smoking or alcohol consumption. METHODS: A case-control study was conducted to analyze the association of TNF-a gene promoter polymorphism with HBV infection outcomes. A total of 207 patients with chronic hepatitis B (HB) and 148 cases of self-limited HBV infection from Ditan Hospital and Shunyi District Hospital in Beijing, respectively were recruited. History of smoking and alcohol drinking was inquired by a questionnaire. The -238G/A polymorphism of TNF-a gene promoter was genotyped by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP). RESULTS: The frequencies of GG and GA genotypes were 98.07% and 1.93% in chronic HB patients and 93.24% and 6.76% in self-limited HBV infection individuals, respectively (X^2=5.30, P=-0.02). The frequency of G allele was significantly higher in patients with chronic HB that in individuals with self-limited HBV infection (99.03% vs 96.62%, X^2=5.20, P=0.02). Only modestly increased risk of onset of chronic HB was found in smokers (OR=1.40, 95% CI: 0.87-2.28, P=0.14) and drinkers (OR=-1.26, 95%CI: 0.78-2.05, P=-0.32). There was a positive interaction between genotype GG and cigarette smoking with an interaction index (Ⅱ) of 2.95, or alcohol consumption with an Ⅱ of 1.64. CONCLUSION: The -238G/A polymorphism of TNF-a gene promoter region is independently associated with different outcomes of HBV infection. 关键词：-238G/A 肿瘤基因多态性坏疽 α因子乙型肝炎病毒传染病中国汉族 HBV 基因型

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Association of -238G/A polymorphism of tumor necrosis factor-alpha gene promoter region with outcomes of hepatitis B virus infection in Chinese Han population

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