Value of Magnetic Resonance Diffusion Weighted Imaging in Evaluating Cellular Density of Astrocytomas

查看全文 作　　者：[1]CHENJun;[2]XIAJun;ZHOUYi-[3]cheng 机构地区：[1]DepartmentofRadiology,RenminHospitalofWuhanUniversity,Wuhan430060,P.R.China;[2]DepartmentofRadiology,theSecondPeople'sHospitalofShenzhen,Shenzhen518035,P.R.China;[3]DepartmentofRadiology,TongjiHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430030,P.R.China 出　　处：《Journal of Nanjing Medical University》索引2004年第18卷第5期,共5页 摘　　要：Objective: To evaluate the value of apparent diffusion coefficients (ADC) in Magnetic Resonance diffusion weighted imaging (MR DWI) with echo-planar technique in depicting the tumor cellularity and grading of astrocytomas. Methods: Thirty-four patients with astrocytomas(18 male, 16 female, ages from 10-73 with average of 38.41) were examined by MRI and proved by surgery and pathology, and the number of grade Ⅰ-Ⅱ (low-grade) and grade Ⅲ-Ⅳ (high-grade) is 26 and 8 respectively. ADC values of astrocytomas were determined on MR DWI. Cellularity of astrocytomas was analyzed with Adobe Photoshop 7.0 software. Results: Mean ADC values of high-grade astrocytomas(7.34±2.95)×10^-4mm^2/s were significantly different from that of lowgrade astrocytomas(13.76±3.31)×10^-4mm^2/s (t=4.913, P<0.001). Cellularity of high-grade astrocytomas (19.81±9.73)% were significantly higher than that of low-grade astrocytomas (4.74±2.96)% (t=4.32,P=0.003). ADC values of astrocytomas significantly negatively correlated with their cellularities (r=-0.535, P=0.001). Conclusion: The cellularities of astrocytomas contribute very much to ADC values in MR DWI. MR DWI is very valuable in predicting and evaluating the cellularity of astrocytomas. MR DWI might have a potential in predicting the degree of astrocytomas. 关 键 词：核磁共振成像 细胞密度 星细胞瘤 肿瘤 神经细胞