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Enhanced antitumor efficacy on hepatoma-bearing rats with adriamycin-loaded nanoparticles administered into hepatic artery

查看全文 作　　者：Jiang-[5]HaoChen;[1]RuiLing;[1]QingYao;[1]LingWang;[1]ZhongMa;[2]YuLi;[3]ZheWang;[4]HuXu 高影响力作者 机构地区：[1]DepartmentofVascularandEndocrineSurgery,XijingHospital,FourthMilitaryMedicalUniversity,Xi'an710033,ShaanxiProvince,China;[2]DepartmentofCellBiology,FourthMilitaryMedicalUniversity,Xi'an710033,ShaanxiProvince,China;[3]DepartmentofPathology,FourthMilitaryMedicalUniversity,Xi'an710033,ShaanxiProvince,China;[4]DepartmentofOrthopaedics,XijingHospital,FourthMilitaryMedicalUniversity,Xi'an710033,ShaanxiProvince,China;[5]DepartmentofVascularandEndocrineSurgery,XijingHospital,FourthMilitaryMedicalUniversity,Xi'an710033,ShaanxiProvince,China高影响力机构 出　　处：《World Journal of Gastroenterology》索引2004年第10卷第13期,共3页高影响力期刊 摘　　要：AIM: To investigate the antitumor activity of adriamycin (ADR) encapsulated in nanoparticles (NADR) and injected into the hepatic artery of hepatoma-bearing rats.METHODS: NADR was prepared by the interfacial polymerization method. Walker-256 carcinosarcomas were surgically implanted into the left liver lobes of 60 male Wistar rats, which were divided into 4 groups at random (15 rats per group). On the 7th day after implantation, normal saline (NS), free ADR (FADR), NADR, or ADR mixed with unloaded nanoparticles (ADR+NP) was respectively injected via the hepatic artery (i.a.) of rats in different groups. The dose of ADR in each formulation was 2.0 mg/kg body weight and the concentration was 1.0 mg/mL. Survival time, tumor enlargement ratio, and tumor necrosis degree were compared between each group.RESULTS: Compared with the rats that received NS i.a.,the rats that received FADR or ADR+NP acquired apparent inhibition on tumor growth, as well as prolonged their life span. Further significant anticancer efficacy was observed in rats that received i.a. administration of NADR. Statistics indicated that NADR brought on a more significant tumor inhibition and more extensive tumor necrosis, as compared to FADR or ADR+NP. The mean tumor enlargement ratio on the 7th day after NADR i.a. was 1.106. The mean tumorbearing survival time was 39.50 days. Prolonged life span ratio was 109.22% as compared with rats that accepted NS.CONCLUSION: Therapeutic effect of ADR on liver malignancy can be significantly enhanced by its nanopaticle formulation and administration via hepatic artery. 关 键 词：抗癌作用 肿瘤 肝细胞瘤 阿霉素 毫微型颗粒 管理方法 肝动脉 ADR
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