GSTM1,GSTT1,GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population:Different pattern of squamous cell carcinoma and adenocarcinoma

查看全文 作　　者：Ahmed [1]Abbas;Karine [1]Delvinquière;Mathilde [1]Lechevrel;Pierre [1]Lebailly;Pascal [1]Gauduchon;Guy [2]Launoy;Fran ois [1]Sichel 机构地区：[1]GRECAN-EA1772 UFR des Sciences Pharmaceutiques,Université de Caen Basse-Normandie et Centre Francois Baclesse,Avenue du Général Harris,14076 Caen cedex 05,France;[2]GRECAN-EA1772 Université de Caen Basse-Normandie et Registre des Tumeurs Digestives du Calvados,UFR de Médecine,Avenue de la C te de Nacre,14032 Caen cedex,France 出　　处：《World Journal of Gastroenterology》索引2004年第10卷第23期,共5页 基　　金：Supported by the Grants From Ligue Nationale Contre le Cancer,Comités Départementaux de la Manche,de l'Orne et du Calvados and from Université de Metz 摘　　要：AIM: To evaluate the association between CYPIA1 and GSTs genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma (SCC) and esophageal adenocarcinorna (ADC) in a high risk area of northwest of France.METHODS: A case-control study was conducted to investigate the genetic polymorphisms of these enzymes (CYPIAI*2C and GSTP1 exon 7 Val alleles, GSTM1 *2/*2 and GSl-l-l*2/*2 null genotypes). A total of 79 esophagealcancer cases and 130 controls were recruited. RESULTS: GSTM2*2/*2 and CYP1A1*1A/*2C genotype frequencies were higher among squamous cell cardnomas at a level close to statistical significance (OR = 1.83, 95% CI0.88-3.83, P= 0.11; OR = 3.03, 95% CI 0.93-9.90, P= 0.07,respectively). For GSTP1 polymorphism, no difference wasfound between controls and cases, whatever their histological status. Lower frequency of GST/-1 deletion was observed in ADC group compared to controls with a statistically significant difference (OR=13.31, 95% CI 1.66-106.92, P<0.01).CONCLUSION: In SCC, our results are consistent with the strong association of this kind of turnout with tobacco exposure. In ADC, our results suggest 3 distinct hypotheses:(1) activation of exogenous procarcinogens, such as small halogenated compounds by GSTTI', (2) contribution of GSTT1 to the inflammatory response of esophageal mucosa, which is known to be a strong risk factor for ADC,possibly through leukotriene synthesis; (3) higher sensitivity to the inflammatory process associated with intracellular depletion of glutathione. 关 键 词：GSTM1 GSTT1 GSTP1 CYPIA1 遗传多态性 感受性 食道癌 肿瘤 法国人口 鳞状细胞癌 腺癌