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Polymorphisms of Renin-angiotensin System in Essential Hypertension in Chinese Tibetans

查看全文 作　　者：[1]BEISUN;[2]TSERINGDRONMA;WEI-[2]JUNQIN;CHAO-[3]YINGCUI;[3]DANTSE;[2]TASHIPINGTSO;[1]YINGLIU;CHANG-[1]CHUNQIU 高影响力作者 机构地区：[1]NationalLaboratoryofMedicalMolecularBiology,InstituteofBasicMedicalSciences,ChineseAcademyofMedicalSciences/PekingUnionMedicalCollege,Beijing100005,China;[2]People'sHospitaloftheTibetAutonomousRegion,TibetAutonomousRegion,Lhasa850000,China;[3]TibetMedicalCollege,TibetAutonomousRegion,Lhasa850000,China高影响力机构 出　　处：《Biomedical and Environmental Sciences》索引2004年第17卷第2期,共8页高影响力期刊 基　　金：This work was supported by grants from the China Medical Board of New York, Inc. (Grant No. CMB 96-657) ;the National Natural Science Foundation of China (Grant No. 39760067 and 39870687). 摘　　要：Objective To evaluate the potential implications of the genetic variability of angiotensin converting enzyme, angiotensinogen and angiotensinⅡtype 1 receptor gene for essential hypertension in Tibetan. Methods A case-control study was conducted in 173 hypertensive individuals and 193 individuals with normal blood pressure. Multiple logistic regression analyses were used to estimate the risks of developing hypertension for different genotypes, and haplotype analyses of the angiotensinogen gene were used to determine the association between two-locus angiotensinogen gene polymorphisms and hypertension. Results As to the risk to high blood pressure and high systolic pressure, women with MM genotype were 7.7 (95% CI: 1.3-20.5) and 8.7 (95% CI: 1.8-20.1) times higher than those with TT genotype after adjustment for age and body mass index. Haplotype frequencies for M235T and G-6A were significantly different between hypertensive individuals and controls, which indicated an association of angiotensinogen gene haplotypes with hypertension, and a significant association of 235T/-6A haplotype with hypotensive effect. Conclusion Our results suggest that angiotensinogen gene 235MM is a predictor for hypertension development in Tibetan women but not in men, and may exert its hypertensive effect on linkage disequilibrum with a possible function locus of G-6A. 关 键 词：基因多态性 血管紧张素原 原发性高血压 西藏 肾素-血管紧张素系统
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