维普中文期刊产品整合服务

Solid-phase Synthesis of Acyl-plasminogen-Streptokinase Activator Composite(APSAC) and Its Thrombolytic Properties

查看全文 作　　者：TENGLi-[1]rong;[1]LIANGFang;[2]SUNHong;[3]QINYi;HONGShui-[1]sheng;[1]CHENJia;LIULan-[1]ying 高影响力作者 机构地区：[1]CollegeofLifeScience,JilinUniversity,Changchun130023,P.R.China;[2]InstituteofBiologicalProducts,Changchun130062,P.R.China;[3]DepartmentofPharmacology,ShenyangPharmaceuticalUniversity,Shenyang110016,P.R.China高影响力机构 出　　处：《Chemical Research in Chinese Universities》索引2004年第20卷第5期,共4页高影响力期刊 基　　金：Supported by the Natural Science Foundation of Jilin Province(No. 2 0 0 3- 0 5 - 5 0 - 2 ) and the Creative Foundation of JilinU niversit 摘　　要：The dialysis method has been traditionally used for the conversion of native human plasminogen(Glu-Hpg) to lys-plasminogen(Lys-Hpg). Here is described a solid-phase synthesis method for the preparation of an acyl-plasminogen-streptokinase activator complex(APSAC) from Lys-Hpg, streptokinase(SK) and chemical modification (agent(4-amidinophenyl-4′-aminobenzoate hydrochloride)) with the L-lysine-Sepharose 4B Column as the carrier. The new method significantly increases the product yield and purity over the liquid-phase methods. The APSAC prepared with the new method exhibits a significant thrombolytic effect with a long half-life of about 8.8 h in rabbits. 关 键 词：固相合成 溶血栓特性 酰基血浆酶原溶栓酶活化剂 赖氨酸 谷氨酸
相关文献

参考文献(12)

引证文献(1)

耦合文献(69)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费