Chronic effect of endosulfan on the testicular functions of rat

查看全文 作　　者：[1]K.C.Chitra;[1]C.Latchoumycandane;[1]P.P.Mathur 机构地区：[1]School of Life Sciences, Pondicherry University, Pondicherry 605 014, India,School of Life Sciences, Pondicherry University, Pondicherry 605 014, India,School of Life Sciences, Pondicherry University, Pondicherry 605 014, India 出　　处：《Asian Journal of Andrology》索引1999年第1卷第4期,共4页 摘　　要：Aim: To find out the toxic effect of endosulfan on the tesficular function of pubertal rats, Methods: Male rats of pu-bertal age were orally administered endosulfan at a dose of 1.0 mg/kg body weight for 30 days. Twenty-four hours af-ter the last tmagnent, the rats were sacrificed and the testis, epididymis, seminal vesicles and ventral prostate were re-moved and weighed. A 10 % testicular homogenate was prepared for biochemical estimations. Results: In endosul-fan-treated rats, there were a reduction in the body weight and the weights of testis and accessory sex organs, a de-crease in the testicular lactate and pyruvate activities, and in the testicular DNA and RNA concentrations, whereas thetesticular protein concentration was slightly increased; the specific activity of testicular steroidogenic enzyme, 33OH-steroid dehydrogenase and the ascorbic acid level were decreased, which were correlated with a decrease in steroidoge-nesis. The lysosomal enzyme acid phosphatase and brush-border enzyme alkaline phosphatase activities were also de-creased in the testis of treated rats. Conclusion: In puhertal rats, endosulfan treaanent inhibits the testicular functions.(Asian J Androl 1999 Dec; 1 : 203 - 206) 关 键 词：杀虫剂 硫丹 睾丸功能 雌激素 老鼠