Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population

查看全文 作　　者：Mohammad [1]Farhadi;Zahra [2]Tahmasebi;Shahin [1]Merat;Farin [3]Kamangar;Dariush [1]Nasrollahzadeh;Reza [1]Malekzadeh

机构地区：[1]Digestive Disease Research Center;[2]Department of Molecular Biology;[3]Cancer Prevention Studies Branch

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第8期,共4页

基　　金：Supported by the Digestive Disease Research Center, Tehran University of Medical Sciences 摘　　要：AIM: To investigate the relation of human papillomavirus (HPV) and esophageal squamous cell carcinoma (ESCC)in Iranian patients as compared to normal controls.METHODS: Using MY09/MY11 consensus primers, we compared the prevalence of a HPV L1 gene in tumor tissues from 38 ESCC cases and biopsied tissues from 38endoscopically normal Iranian individuals. We also compared the presence of HPV16 and HPV18 in the same samples using type-specific E6/E7 primers.RESULTS: Fourteen (36.8%) of the 38 ESCC samples but only 5 (13.2%) of the 38 control samples were positive for the HPV L1 gene (P = 0.02). Five (13.2%) of the ESCC samples but none of the control samples were positive for the HPV16 E6/E7gene (P = 0.05). Three (7.9%) of the ESCC samples and 5 (13.2%) of the control samples were positive for the HPV18 E6/E7gene (P = 0.71).CONCLUSION: Our data are consistent with HPV DNA studies conducted in other high-risk areas for ESCC. HPV should be considered as a potential factor contributing to the high incidence of ESCC in Iran and other high-incidence areas of the world. 关键词：乳头瘤病毒食道鳞状细胞癌疾病调查流行病学

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Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population

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