Adiponectin as a protective factor in hepatic steatosis

查看全文 作　　者：Nahum Méndez-[1]Sánchez;Norberto C.Chávez-[1]Tapia;Antonio [2]R.Villa;Karla Sánchez-[1]Lara;Daniel Zamora-[1]Valdés;Martha [1]H.Ramos;Misael [1]Uribe

机构地区：[1]Liver Research Unit;[2]Clinical Epidemiology Unit

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第12期,共5页

摘　　要：AIM: Obesityand insulin resistance (IR) are closely related to hepatic steatosis (HS), and adiponectin is a hepatic insulin sensitizer that has important effects in liver function.This study aims at investigating the relationship between serum adiponectin concentration and the presence of HS.METHODS: We carried out a cross-sectional study in a check-up unit of a University Hospital in Mexico City. We enrolled 196 subjects, comprising 98 subjects with HS (27 women, 71 men) and 98 controls (37 women and 61men). Anthropometric, metabolic and biochemical variables were measured in the two groups. Serum adiponectin and leptin concentrations were determined,their association with grade of HS tested, and concentrations,according to quartiles, compared between cases and controls. χ2 analysis for linear trends was used to test for a dose-response relationship and logistic regression analysis was conducted to test for a protective effect of adiponectin.RESULTS: The HS subjects were older and more obese than controls, with a central obesity pattern. In the fourth quartile of adiponectin concentrations, HS was less common and severe. In a multivariate model of the fourth quartile of the adiponectin concentrations, we observed a protective effect (OR = 0.17, 95%CI: 0.04-0.67, P= 0.01).In subjects with more severe HS, we observed higher leptin concentrations, and caloric intakes, total fat and iron consumption were higher than in controls.CONCLUSION: The results of the present study suggest that a high serum concentration of adiponectin is associated with a protective effect against HS. 关键词：脂肪肝保护机制胰岛素抵抗肥胖

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Adiponectin as a protective factor in hepatic steatosis

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