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Application of serum surface-enhanced laser desorption/ionization proteomic patterns in distinguishing lung cancer patients from healthy people

查看全文 作　　者：YANGShuan-[1]ying;XIAOXue-[2]yuan;ZHANGWang-[1]gang;SUNXiu-[1]zhen;ZHANGLi-[2]juan;[3]ZHANGWei;[3]ZHOUBin;CHENGuo-[1]an;HEDa-[2]cheng 高影响力作者 机构地区：[1]DepartmentofRespiratoryMedicine;[2]KeyLaboratoryforCellProliferationandRegulationBiologyMinistryofEducation,BeijingNormalUniversity,Bejing100875,China;[3]GeneralThoracicSurgery高影响力机构 出　　处：《Chinese Medical Journal》索引2005年第12期,共4页高影响力期刊 基　　金：ThisworkwassupportedbyagrantfromtheShaanxiScienceandTechnologyDevelopmentProgram [No 2004K13 G3 (3) ] 摘　　要：Screening and early diagnosis of lung cancer relies mainly on chest X-ray, low-dose computed tomography, bronchoscopy, sputum cytology, and measurement of tumor markers such as carcinoembryonic antigen (CEA), cytokeratin-19 fragments (Cyfra21-1), and neuron-specific enolase (NSE). However, all these methods lack adequate sensitivity and/or specificity. 1-3 Better methods are therefore urgently needed in screening and early diagnosis of lung cancer, and proteomic fingerprinting represents a promising approach. Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS), an innovative proteomic technology, has overcome many of the limitations of two-dimensional electrophoresis (2D) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). 4,5 Recently, this technology has been successfully used to distinguish pancreatic, ovarian and prostate cancer patients from healthy control subjects. 5-7 The aim of the current study was to investigate the application of serum SELDI protein profiling in distinguishing lung cancer patients from healthy persons. 关 键 词：血清检查 激光解吸附 电离模式 肺癌 健康状态
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