Transformation of hepatitis B serologic markers in babies born to hepatitis B surface antigen positive mothers

查看全文 作　　者：Jian-[1]SheWang;[2]HuiChen;Qi-[1]RongZhu

机构地区：[1]LaboratoryofInfectiousDiseases,Children'sHospitalofFudanUniversity;DepartmentofPediatrics,ShanghaiMedicalCollegeFudanUniversity,Shanghai200032,China;[2]DepartmentofInfectiousDiseases,Children'sHospitalofFudanUniversity;DepartmentofPediatrics,ShanghaiMedicalCollegeFudanUniversity,Shanghai200032,China

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第23期,共4页

基　　金：Supported by the Key-Subject Construction Project of Ministry of Public Health of China,No.97030223the young researcher grant from Children's Hospital of Fudan University,No.QN2001-5 Co-first-authors: Jian-She Wang and Hui Chen 摘　　要：AIM: To better understand the clinical significance of hepatitis B serologic markers in babies born to hepatitis B surface antigen (HBsAg) positive mothers, the incidence of maternal serologic markers of hepatitis B via placenta and its transformation in these babies were investigated.METHODS: Mothers with positive HBsAg were selected in the third trimester of pregnancy. Their babies received immunoprophylaxis with hepatitis B immunoglobulin and hepatitis B vaccine after birth, and were consecutively followed up for hepatitis B serologic markers and HBV DNA at birth, mo 1, 4, 7, 12, and 24. RESULTS: Forty-two babies entered the study, including 16 born to hepatitis B e antigen (HBeAg)-positive HBsAg carrier mothers and 26 to HBeAg-negative HBsAg carrier mothers. Apart from four babies born to HBeAg-positive carrier mothers and demonstrated persistent positive HBeAg eventually became HBV carriers, all other babies developed anti-HBs before 12 mo of age. Among the other 12 babies born to HBeAg-positive carrier mothers,HBeAg was detected in 7 at birth, in 4 at mo 1, and in none of them thereafter. No antibody response to the transplacental HBeAg was detected. Among the babies born to HBeAg-negative carrier mothers, anti-HBe was detected 100% at birth and mo 1, in 88.5% at mo 4, in 46.2% at mo 7, in 4.2% at mo 12 and none in mo 24. Among all the immunoprophylaxis-protected babies born to either HBeAg-positive or HBeAg-negative carrier mothers, anti-HBc was detected in 100% at birth, mo 1 and mo 4, in 78.9% at mo 7, in 36.1% at mo 12 and in none at mo 24.CONCLUSION: HBeAg can pass through human placenta from mother to fetus and become undetectable before 4 mo of age, but no antibodies response to the transplacental HBeAg can be detected till mo 24 in the immunoprophylaxisprotected babies. The sole existence of anti-HBe before 1 year of age or anti-HBc before 2 years of age in babies born to HBsAg carrier mothers may simply represent the transplacental maternal antibodies, instead of indicators of HBV infection status. 关键词：乙型肝炎病毒血清学标记新生儿病毒表面抗原母婴传播

相关文献

参考文献（20）
引证文献（40）
耦合文献（143）

参考文献(20)

引证文献(40)

耦合文献(143)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Transformation of hepatitis B serologic markers in babies born to hepatitis B surface antigen positive mothers

参考文献(20)

引证文献(40)

耦合文献(143)

用户提示