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Expression of macrophage migration inhibitory factor is associated with enhanced angiogenesis and advanced stage in gastric carcinomas

查看全文 作　　者：Chia-Tung [1]Shun;Jaw-Town [2]Lin;Shih-Pei [2]Huang;Min-Tsan [3]Lin;Ming-Shiang [2]Wu 高影响力作者 机构地区：[1]Department of Forensic Medicine and Pathology;[2]Department of Internal Medicine and Primary Care Medicine;[3]Department of Surgery高影响力机构 出　　处：《World Journal of Gastroenterology》索引2005年第11卷第24期,共5页高影响力期刊 基　　金：Supported by the Grants From National Science Council (NSC2314-B002-122,123,124), Executive Yuan, Taiwan, China 摘　　要：AIM: Macrophage migration inhibitory factor (MIF) was reported to inactivate p53 and play an essential role in the growth and angiogenesis of tumors that arise at sites of chronic inflammation. Gastric inflammation is a prerequisite for the development of gastric carcinoma (GC), which has recently been linked to Helicobacter pylori(H pylori)infection. This study aimed to investigate dinicopathologicalsignificance of MIF expression in GCs.METHODS: We selected 90 consecutive patients with GCs for investigation of the relation among MIF status, clinicopathological parameters, p53 expression and angiogenesis. MIF and p53 expression was assessed by immunohistochemistry as positive and negative groups. Tumor vascularity was evaluated by counting microvessel density on anti-CD34 stained sections. Expression status of MIF was correlated with determined clinicopathological data, p53 immunoreactivity and microvessel counts.RESULTS: Strong immunostainings of MIF were observed in the cytoplasm of cancerous cells in 40% (36/90) of cases but not in normal or metaplastic epithelia. There was no statistically significant correlation between MIFexpression and age, gender, H pylori infection, tumor location, histological subtypes, lymph node metastasis or p53 expression. Early GC less frequently overexpressed MIFas compared to advanced GCs (4/20 vs 32/70, P = 0.04).A remarkably increased microvessel count was noted inGCs with MIF expression than those without MIF expression (55.1±30.1 vs 31.3±28.8, P= 0.0001).CONCLUSION: Our results suggest that expression of MIF may contribute to the progression and enhanced angiogenesis in a substantial portion of GCs. 关 键 词：巨噬细胞移植 基因表达 胃癌 病理机制
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