The interaction of versican with its binding partners

查看全文 作　　者：Yao Jiong [1,3]WU;David P. LA [1,3]PIERRE;Jin [2]WU;Albert J. [1]YEE;Burton B. [1,3]YANG

机构地区：[1]Sunnybrook & Women's College Health Sciences Centre, 2075 Bayview Avenue, Toronto M4N 3M5 Canada;[2]School of Chinese Medicine, The University of Hong Kong, Hong Kong SAR, China;[3]Department of Laboratory Medicine and Pathobiology,University of Toronto,Canada

出　　处：《Cell Research》索引2005年第15卷第7期,共12页

摘　　要：Versican belongs to the family of the large aggregating chondroitin sulfate proteoglycans located primarily within theextracellular matrix (ECM). Versican, like other members of its family, has unique N- and C-terminal globular regions,each with multiple motifs. A large glycosaminoglycan-binding region lies between them. This review will begin byoutlining these structures, in the context of ECM proteoglycans. The diverse binding partners afforded to versican byvirtue of its modular design will then be examined. These include ECM components, such as hyaluronan, type Icollagen, tenascin-R, fibulin-1, and -2, fibrillin-1, fibronectin, P- and L-selectins, and chemokines. Versican also binds tothe cell surface proteins CD44, integrin β1, epidermal growth factor receptor, and P-selectin glycoprotein ligand-1.These multiple interactors play important roles in cell behaviour, and the roles of versican in modulating such processesare discussed. 关键词：交互作用粘合物细胞外矩阵蛋白聚糖粘多糖

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The interaction of versican with its binding partners

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耦合文献(35)

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