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Correlation between expression of cyclooxygenase-2 and the presence of inflammatory cells in human primary hepatocellular carcinoma: Possible role in tumor promotion and angiogenesis

查看全文 作　　者：Melchiorre [1]Cervello;Daniela [1]Foderà;Ada Maria [2]Florena;Maurizio [3]Soresi;Claudio [2]Tripodo;Natale D'[4]Alessandro;Giuseppe [3]Montalto 高影响力作者 机构地区：[1]Institute of Biomedicine and Molecular Immunology 'Alberto Monroy';[2]Institute of Pathologic Anatomy;[3]Department of Clinical Medicine;[4]Department of Pharmacological Science高影响力机构 出　　处：《World Journal of Gastroenterology》索引2005年第11卷第30期,共6页高影响力期刊 基　　金：Supported by the MIUR and Progetto Strategico Oncologia 'Terapia Preclinica Moleculare Oncologia' MIUR-CNR 摘　　要：AIM: To investigate the association of cyclooxygenase-2(COX-2) expression with angiogenesis and the number and type of inflammatory cells (macrophages/Kupffer cells;mast cells) within primary hepatocellular carcinoma (HCC)tissues and adjacent non-tumorous (MT) tissues.METHODS: Immunohistochemistry for COX-2, CD34,CD68 and mast cell tryptase (MCT) was performed on 14 well-characterized series of liver-cirrhosis-associated HCC patients. COX-2 expression and the number of inflammatory cells in tumor lesions and surrounding liver tissues of each specimen were compared. Moreover,COX-2, CD34 staining and the number of inflammatory cells in areas with different histological degrees within each tumor sample were comparatively analyzed.RESULTS: The percentage of COX-2 positive cells was significantly higher in NT tissues than in tumors. COX-2 expression was higher in well-differentiated HCC than in poorly-differentiated tissues. Few mast cells were observed within the tumor mass, whereas a higher number was observed in the surrounding tissue, especially in peri-portal spaces of NT tissues. Abundant macrophages/Kupffer cells were observed in NT tissues, whereas the number of cells was significantly lower in the tumor mass.However, a higher cell number was observed in the well-differentiated tumor and progressively decreased in relation to the differentiation grade. Within the tumor, a positive correlation was found between COX-2 expression and the number of macrophages/Kupffer cells and mast cells. Moreover, there was a positive correlation between CD34 and COX-2 expression in tumor tissues. Comparison between well- and poorly-differentiated HCC showed that the number of CD34-positive cells decreased with dedifferentiation. However, COX-2 was the only independent variable showing a positive correlation with CD34 in a multivariate analysis.CONCLUSION: The presence of inflammatory cells and COX-2 expression in liver tumor suggests a possible relationship with tumor angiogenesis. COX-2 expressing cells and the number of macrophages/Kupffer cells and mast cells decrease with progression of the disease. 关 键 词：三氧化酶-2 基因表达 炎性细胞 原发性肝细胞癌 肿瘤转移 病理机制
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