Role of potassium in acid secretion

查看全文 作　　者：John P [1]Geibel

机构地区：[1]Professor of Surgery and Cellular and Molecular Physiology Director of Surgical Research, Yale University School of Medicine, CT, United States

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第34期,共7页

摘　　要：Potassium (K+) ions are critical for the activation and catalytic cycle of the gastric H+,K+-ATPase, resulting in the secretion of hydrochloric acid into the parietal cell canaliculus. As both symptom, severity and esophageal mucosal damage in gastro-esophageal reflux disease (GERD) are related to the degree of acid exposure, K+ is a logical target for approaches to inhibit acid production.The probable K+ binding site on the gastric H+,K+-ATPase has recently been described and studies are elucidating how K+ activates the enzyme. K+ channels in the apical membrane of the parietal cell are implicated in the recycling of K+ and, to date, three potential K+ channels (KCNQ1, Kir2.1 and Kir4.1) have been identified. The channels represent theoretical sites for agents to control acid secretion but it will be difficult to develop selective blockers. An alternative strategy is to prevent K+ from activating gastric H+,K+-ATPase; the potassiumcompetitive acid blocker (P-CAB) class inhibits acidsecretion by binding at or near the K+ binding site.Ongoing research is further defining the role of K+ in the functioning of the gastric H+,K+-ATPase, as well as determining the clinical utility of agents directed toward this important cation. 关键词：钾离子活化作用胃疾病氯化氢分泌物食管反流性疾病

相关文献

参考文献（68）
引证文献（7）
耦合文献（2）

参考文献(68)

引证文献(7)

耦合文献(2)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Role of potassium in acid secretion

参考文献(68)

引证文献(7)

耦合文献(2)

用户提示