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Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation

查看全文 作　　者：Annie OO [1]Chan;Cecilia [2]Cheng;Wai Mo [1]Hui;Wayne HC [1]Hu;Nina YH [1]Wong;KF [3]Lam;Wai Man [1]Wong;Kam Chuen [1]Lai;Shiu Kum [1]Lam;Benjamin CY [1]Wong 高影响力作者 机构地区：[1]Department of Medicine the University of Hong Kong, Hong Kong, China;[2]Division of Social Science the Hong Kong University of Science and Technology, Hong Kong, China;[3]Department of Medicine the University of Hong Kong, Hong Kong, China Department of Statistics, the University of Hong Kong, Hong Kong, China高影响力机构 出　　处：《World Journal of Gastroenterology》索引2005年第11卷第34期,共5页高影响力期刊 摘　　要：AIM: To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 controls.METHODS: Constipation was diagnosed by Rome Ⅱ criteria.Coping ability and anxiety/depression were assessed by validated questionnaires. Transit time and balloon distension test were performed.RESULTS: 34.5% patients were classified as slow transit type of constipation. The total colonic transit time (56 h vs 10 h, P<0.0001) and rectal sensation including urge sensation (79 mL vs 63 mL, P = 0.019) and maximum tolerable volume (110 mL vs95 mL, P = 0.03) differed in patients and controls. Constipated subjects had significantly higher anxiety and depression scores and lower SF-36 scores in all categories. They also demonstrated higher scores of'monitoring' coping strategy (14+6 vs9+3, P = 0.001),which correlated with the rectal distension sensation (P = 0.005), urge sensation (P=0.002), and maximum tolerable volume (P = 0.035). The less use of blunting strategy predicted slow transit constipation in both univariate (P = 0.01) and multivariate analysis (P = 0.03).CONCLUSION: Defective or ineffective use of coping strategies may be an important etiology in functional constipation and subsequently reflected in abnormal anorectal physiology. 关 键 词：肛门 直肠 生理学 功能性便秘 病理机制
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