Anti-tumor effect of thalidomide and paclitaxel on hepatocellular carcinoma in nudemice

查看全文 作　　者：ZHANG Zhong-lin LIU Zhi-su SUN [1]Quan

机构地区：[1]Department of General Surgery, Zhongnan Hospital, WuhanUniversity, Wuhan 430071, China

出　　处：《Chinese Medical Journal》索引2005年第20期,共7页

摘　　要：Background Thalidomide is reviving for its antiangiogen ic effect on corneal neovascularization models. Recently, it has been employed in tumor research in several types of solid carcinomas. However, its effect on hepatocellular carcinoma (HCC) has not yet been clarified. Methods A total of 48 nude mice bearing human HCC with a high m etastatic potential were randomly divided into 4 groups. Thalidomide (200 mg/kg ), paclitaxel (13 mg/kg), or their combination, which was dissolved in 0.5% sod ium carboxyl methyl cellulose (CMC) suspension, was intraperitoneally injected i n each group since the second day of the establishment of animal model. The gro up simply administered with 0.5% CMC was set as placebo-control. The mice wer e sacrificed on the 30th day, for the measurement of tumor size, weight and meta stasis in the lungs. The levels of CD 34 and endothelial growth factor (VE GF) mRNA in tumor tissues were detected by immunohistochemistry and semiquantita tive RT-PCR, respectively, and microvessel density (MVD) was evaluated. Results No statistical difference was found in tumor weight and volume between the thalidomide group and control (P>0.05). Paclitaxel sho wed a growth-inhibiting effect on tumors (P<0.05). The value of MVD and V EGF mRNA and metastases to the lungs in each group were lower than those in the placebo-control group (P<0.05); such difference in the combination group w as statistically significant (P<0.05). Conclusions Paclitaxel, but not thalidomide, has significant gr owth inhibitory effect on tumors, but both significantly inhibit angiogenesis an d metastasis of human HCC in nude mice, such effects of paclitaxel can be amplif ied by thalidomide. 关键词：抗肿瘤作用安眠药肝细胞癌裸鼠动物实验

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Anti-tumor effect of thalidomide and paclitaxel on hepatocellular carcinoma in nudemice

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