Association between thyroid function and gallstone disease

查看全文 作　　者：Henry V[1]lzke;Daniel M [2]Robinson;Ulrich [1]John

机构地区：[1]Ernst Moritz Arndt University Greifswald Institute of Epidemiology and Social Medicine, Walther Rathenau Str. 48, D-17487 Greifswald, Germany;[2]Ernst Moritz Arndt University Greifswald Department of Medicine B,Friedrich Loeffler Str. 23a, D-17487 Greifswald, Germany

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第35期,共5页

基　　金：Supported by the German Federal Ministry for Education and Research, No. 01ZZ96030, from the Ministry for Education, Research and Cultural Affairs and the Ministry for Social Affairs of the State Mecklenburg-West Pomerania 摘　　要：AIM: To investigate those associations using data of the population-based Study of Health in Pomerania.METHODS: A study population of 3 749 residents aged 20-79 years without previously diagnosed thyroid disease was available for analyses. Serum TSH was used to assess thyroid function. Cholelithiasis was defined by either a prior history of cholecystectomy or the presence of gallstones on ultrasound. Logistic regression was performed to analyze independent associations between thyroid function and cholelithiasis.RESULTS: There were 385 persons (10.3%) with low (<0.3 mIU/L), 3 321 persons (88.6%) with normal and 43 persons (1.2%) with high serum TSH levels (>3 mIU/L).The proportion of cholelithiasis among males and females was 14.4% and 25.3%, respectively. Among males, there was an independent relation between high serum TSH and cholelithiasis (OR 3.77; 95%-CI 1.06-13.41; ,P<0.05). zAlso among males, there was a tendency towards an elevated risk of cholelithiasis in persons with low serum TSH (OR 1.40; 95%-CI 0.96-2.02; P = 0.07). In the female population, no such relation was identified.CONCLUSION: There is an association between thyroid and gallstone disease with a gender-specific relation between hypothyroidism and cholelithiasis. 关键词：甲状腺软骨胆结石病理机制临床表现

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Association between thyroid function and gallstone disease

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