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The polymorphism of heat shock protein 70 genes in Chinese Han population in Fujian province

查看全文 作　　者：JING AN [1]LIN;WEN QING [2]LI;DE FE [3]YE;YUE YONG [3]ZHU 高影响力作者 机构地区：[1]Center of Research the First Affiliated Hospital, Fujian Medical University, Fuzhou, P. R. China;[2]Department of Gastroenterology the First Affiliated Hospital, Fujian Medical University, Fuzhou, P. R. China;[3]Department of Rheumatology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, P. R. China高影响力机构 出　　处：《Journal of Microbiology and Immunology》索引2005年第3卷第3期,共6页高影响力期刊 摘　　要：To understand the polymorphism of the heat shock protein 70 (HSP70) genes in Chinese Han population and to explore the co-relations between HSP70 polymorphism and disease, three polymorphic loci of HSP70 genes in 127 healthy Chinese Han population in Fujian province were analyzed by PCR and restriction enzyme analysis, and the genotypes and allele frequencies of HSP70 in different populations from various area were compared. It was found that the proportions of HSP70-1 genotypes GG, GC and CC among Chinese Han population in Fujian province were 55.1%, 40.2% and 4.7% respectively, while those of HSP70-2 genotypes AA, AG and GG were 44.1%, 48.8% and 6.9% respectively, and those of HSP70-hom genotypes TT, TC and CC were 59.8%, 37.0% and 3.2% respectively. The allele frequencies of G and C in HSP70-1 were 75.2% and 24.8%; those of A and G in HSP70-2 were 68.5% and 31.5% and those of T and C in HSP70-hom were 78.3% and 21.7% respectively. The distribution of the HSP70-1 polymorphisms in Chinese Han population was almost the same as those in Japanese and Mexican populations, but it was rather different from those of American and Spanish populations with a significant differences. Meanwhile, the frequency of GG homozygote in HSP70-1 was significantly higher than those in American and Spanish populations. No significant difference was found in the distribution of HSP70-2 polymorphism between Chinese and Japanese populations, in which the differences among American, Mexican and Spanish populations were quite obvious. The frequency of AA homozygote in HSP70-2 was significantly higher than those in Mexican, American and Spanish populations, while, the distribution of HSP 70-hom genotype and allele frequency in Chinese Han population was almost just the same as those in Japanese and Mexican populations. Furthermore, it was also found that the genotype distribution and allele frequencies of the HSP70 genes in Han population of Fujian province were almost the same as those in Han population in Taiwan, but they were different in certain loci from those of Han population in Wuhan area. It is evident that the distribution of HSP70 gene polymorphisms among Chinese Han population are different from other regions in the world. 关 键 词：基因多态性 热休克蛋白70 中国 福建 汉族
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