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Etiology and functional status of liver cirrhosis by ^(31)P MR spectroscopy

查看全文 作　　者：Monika [1,2]Dezortova;Pavel [3,4]Taimr;Antonin [1,2]Skoch;Julius [3,4]Spicak;Milan [1,2]Hajek 高影响力作者 机构地区：[1]MR Unit;[2]Institute for Clinical and Experimental Medicine, Prague, Czech Republic;[3]Department of Hepatogastroenterology;[4]Institute for Clinical and Experimental Medicine高影响力机构 出　　处：《World Journal of Gastroenterology》索引2005年第11卷第44期,共6页高影响力期刊 基　　金：Supported by grant from Ministry of Health IGA 7853-3, and MZO 00023001, Czech Republic 摘　　要：AIM: To assess the functional status and etiology of liver cirrhosis by quantitative 31p magnetic resonance spectroscopy (MRS).METHODS: A total of 80 patients with liver cirrhosis of different etiology and functional status described by Child-Pugh score were examined and compared to 11 healthy volunteers. MR examination was performed on a 1.5 T imager using a 1H/31P surface coil by the 2D chemical shift imaging technique.Absolute concentrations of phosphomonoesters (PME),phosphodiesters (PDE), inorganic phosphate (Pi) and adenosine triphosphate (ATP) were measured.RESULTS: MRS changes reflected the degree of liver dysfunction in all the patients as well as in individual etiological groups. The most important change was a decrease of PDE. It was possible to distinguish alcoholic,viral and cholestatic etiologies based on MR spectra.Alcoholic and viral etiology differed in PDE (alcoholic,viral, controls: 6.5±2.3, 6.5±3.1, 10.8±2.7 mmol/L,P<0.001) and ATP (alcoholic, viral, controls: 2.9±0.8, 2.8±0.9, 3.7±1.0 mmol/L, P<0.01) from the control group.Unlike viral etiology, patients with alcoholic etiology also differed in Pi (alcoholic, controls: 1.2±0.4, 1.6±0.6mmol/L, P<0.05) from controls. No significant changes were found in patients with cholestatic disease and controls; nevertheless, this group differed from both alcoholic and viral groups (cholestatic, alcoholic, viral: 9.4±2.7, 6.5±2.3, 6.5±3.1 mmol/L, P<0.005) in PDE.CONCLUSION: 31p MRS can significantly help in noninvasive separation of different etiological groups leading to liver cirrhosis. In addition, MRS changes reflect functional liver injury. 关 键 词：病原学 肝硬化 MR 光谱学
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