Excessive portal flow causes graft failure in extremely small-for-size liver transplantation in pigs

查看全文 作　　者：Hong-Sheng [1]Wang;Nobuhiro [2]Ohkohchi;Yoshitaka [1]Enomoto;Masahiro [1]Usuda;Shigehito [1]Miyagi;Takeshi [1]Asakura;Hiroo [1]Masuoka;Takashi [1]Aiso;Keisuke [1]Fukushima;Tomohiro [1]Narita;Hideyuki [1]Yamaya;Atsushi [1]Nakamura;Satoshi [1]Sekiguchi;Naoki [1]Kawagishi;Akira [1]Sato;Susumu [1]Satomi

机构地区：[1]Division of Advanced Surgical Science and Technology;[2]Department of Surgery

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第44期,共6页

基　　金：Supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan, the Ministry of Welfare of Japan, and by a grant from Graduate School of Medicine, Tohoku University 摘　　要：AIM: To evaluate the effects of a portocaval shunt on the decrease of excessive portal flow for the prevention of sinusoidal microcirculatory injury in extremely smallfor-size liver transplantation in pigs.METHODS: The right lateral lobe of pigs, i.e. the 25%of the liver, was transplanted orthotopically. The pigs were divided into two groups: graft without portocaval shunt (n = 11) and graft with portocaval shunt (n=11).Survival rate, portal flow, hepatic arterial flow, and histological findings were investigated.RESULTS: In the group without portocaval shunt, all pigs except one died of liver dysfunction within 24 h after transplantation. In the group with portocaval shunt,eight pigs survived for more than 4 d. The portal flow volumes before and after transplantation in the group without portocaval shunt were 118.2±26.9 mL/min/100 g liver tissue and 270.5±72.9 mL/min/100 g liver tissue,respectively. On the other hand, in the group with portocaval shunt, those volumes were 124.2±27.8 mL/min/100 g liver tissue and 42.7±32.3 mL/min/100 g liver tissue, respectively (P<0.01). As for histological findings in the group without portocaval shunt, destruction of the sinusoidal lining and bleeding in the peri-portal areas were observed after reperfusion, but these findings were not recognized in the group with portocaval shunt.CONCLUSION: These results suggest that excessive portal flow is attributed to post transplant liver dysfunction after extreme small-for-size liver transplantation caused by sinusoidal microcirculatory injury. 关键词：白内障肝移植猪动物实验

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Excessive portal flow causes graft failure in extremely small-for-size liver transplantation in pigs

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