Polymorphisms in sulfotransferase 1A1 and glutathione 5-transferase P1 genes in relation to colorectal cancer risk and patients' survival

查看全文 作　　者：Xiao-Feng [1]Sun;Ahmad [1]Ahmadi;Gunnar [3]Arbman;Asa [2]Wallin;Daniel [2]Asklid;Hong [1]Zhang

机构地区：[1]Department of Oncology, Institute of Biomedicine and Surgery, University of Linkoping, Linkoping, Sweden;[2]Daniel Asklid, Hong Zhang, Department of Cell Biology, Institute of Biomedicine and Surgery, University of Linkoping, Linkoping, Sweden;[3]Department of Surgery, Vrinnevi Hospital, Norrkoping, Sweden

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第43期,共5页

基　　金：Supported by grants from the Swedish Cancer Foundation and the Health Research Council in the South-East of Sweden 摘　　要：AIM: To examine whether polymorphisms in SULT1A1 and GSTP1 genes contribute to colorectal cancer development and whether they are associated with clinicopathological variables are not well identified.METHODS: We examined the genotypes of 125colorectal cancer patients and 666 healthy controls in a Swedish population by using PCR-restriction fragment length polymorphism (RFLP).RESULTS: SULT1A1*2/*2 genotype (OR=2.49,95%CI=1.48-4.19, P=0.0002) and *2 allele (OR=1.56, 95%CI = 1.16-2.10, P = 0.002) had an effect on colorectal cancer susceptibility, while GSTP1 genotype was without effect. However, GSTP1 G-type predicted a worse prognosis in the patients independently of gender,age, Dukes'stage, growth pattern, and differentiation (P=0.03).CONCLUSION: Polymorphism in SULT1A1 may predispose to colorectal cancer and GSTP1 may be a biological indicator of prognosis in the patients. 关键词：基因多态性磺基转移酶 1A1 谷胱甘肽结肠癌直肠癌

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Polymorphisms in sulfotransferase 1A1 and glutathione 5-transferase P1 genes in relation to colorectal cancer risk and patients' survival

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