Helicobacter pylori-infected animal models are extremely suitable for the investigation of gastric carcinogenesis

查看全文 作　　者：Masaaki [1]Kodama;Kazunari [1]Murakami;Ryugo [1]Sato;Tadayoshi [1]Okimoto;Akira [2]Nishizono;Toshio [1]Fujioka

机构地区：[1]Department of Gastroenterology;[2]Department of Infectious Diseases (Microbiology)

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第45期,共9页

摘　　要：Although various animal models have been developed to clarify gastric carcinogenesis, apparent mechanism of gastric cancer was not clarified in recent years. Since the recognition of the pathogenicity of Helicobacter pylori (Hpylori), several animal models with Hpylori infection have been developed to confirm the association between Hpylori and gastric cancer. Nonhuman primate and rodent models were suitable for this study. Japanese monkey model revealed atrophic gastritis and p53mutation after long-term infection of Hpylori. Mongolian gerbil model showed the development of gastric carcinoma with H pylori infection alone, as well as with combination of chemical carcinogens, such as N-methylN-nitrosourea and N-methyl-N-nitro-N'-nitrosoguanidine.The histopathological changes of these animal models after Hpylori inoculation are closely similar to those in human beings with Hpylori infection. Eradication therapy attenuated the development of gastric cancer in Hpyloriinfected Mongolian gerbil. Although several features of animal models differ from those seen in human beings,these experimental models provide a starting point for further studies to clarify the mechanism of gastric carcinogenesis as a result of Hpylori infection and assist the planning of eradication therapy to prevent gastric carcinoma. 关键词：幽门螺杆菌细菌感染动物模型胃癌

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Helicobacter pylori-infected animal models are extremely suitable for the investigation of gastric carcinogenesis

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