Effects of L-carnitine in patients with hepatic encephalopathy

查看全文 作　　者：Mariano [1]Malaguarnera;Giovanni [1]Pistone;Rampello [1]Elvira;Carmelo [1]Leotta;Linda [1]Scarpello;Rampello [2]Liborio

机构地区：[1]Department of Senescence;[2]Department of Neurosciences

出　　处：《World Journal of Gastroenterology》索引2005年第11卷第45期,共6页

摘　　要：AIM: To evaluate the influence of L-carnitine on mental conditions and ammonia effects on patients with hepatic encephalopathy (HE).METHODS: One hundred and fifty patients (10 patients with alcoholism, 41 patients with hepatitis virus B infection, 78 patients with hepatitis C virus infection,21 patients with cryptogenetic cirrhosis) meeting the inclusion criteria were randomized into group A receiving a 90-d treatment with L-carnitine (2 g twice a day) or into group B receiving placebo in double blind.RESULTS: At the end of the study period, a significant decrease in NH4 fasting serum levels was found in patients with hepatic encephalopathy (P<0.05) afler the treatment with levocarnitine (LC). Significant differences were also found between symbol digit modalities test and block design in patients with hepatic encephalopathy (P<0.05).CONCLUSION: Results of our study suggest an important protective effect of L-carnitine against ammonia-precipitated encephalopathy in cirrhotic patients. 关键词：L-肉毒素肝性脑病治疗临床表现

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Effects of L-carnitine in patients with hepatic encephalopathy

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