Significance of VEGF and NF-κB Expression in Thyroid Carcinoma

查看全文 作　　者：Zhenxian [1]Du;Haiyan [1]Zhang;Daxin [2]Gao;Huaqin [3]Wang;Yongjun [4]Li;Guoliang [1]Liu

机构地区：[1]Department of Endocrinology and Metabolism, The First Affiliated Hospital,China Medical University, Shenyang 110001. China.;[2]Department of Orthopedics, The First Municipal Hospital of Qinhuangdao,Qinhuangdao 066000, China.;[3]Department of Neurology, Kyoto University Graduate School of Medicine,Kyoto 606-8507, Japan.;[4]Department of Experimental Pathology,China Medical University, Shenyang 110001, China.

出　　处：《Chinese Journal of Clinical Oncology》索引2006年第3卷第3期,共6页

摘　　要：OBJECTIVE To investigate the significance of vascular endothelial growth factor (VEGF) and nuclear factor-kappaB (NF-κB) expression in thyroid carcinoma. METHODS The expression of NF-κB and VEGF was determined by im- munohistochemistry in formalin-fixed and paraffin-embedded specimens obtained from 10 normal thyroid tissues (NT), 12 cases of thyroid adeno- ma (TA) and 68 cases of thyroid carcinoma (TC).Differences in expres- sion between NT, TA and TC were statistically analyzed. In addition, in cases of TC, the relationship of NF-κB and VEGF expression with various clinicopathological factors, including histological typing, clinical staging and lymph node metastasis, as well as the correlation between N F - κ B and VEGF expression was examined. RESULTS In contrast to the negative immunoreactivity for VEGF in NT, there was a significantly higher positive incidence (PI) in TA (41.7%, P= 0.040) and TC (75.0%, P<0.001), and a significant difference between TA and TC (P=0.036). Immunoreactivity for NF-κB in NT was negative and significantly higher in TC (63.2%, P<0.001),but not in TA (16.7%, P= 0.481). However the PI difference between TA and TC (P=0.003) was significant. Between the histological types of TC, a significantly higher PI was found in undifferentiated thyroid carcinoma (UTC),namely,100% for VEGF and 90.0% for NF-κB. We also found significant positive relation- ships of VEGF and N F - κ B expression with the clinical stage and lymph node metastasis. Furthermore, a significant positive correlation between VEGF and NF-κB expression in TC was observed. CONCLUSION Our data showed that the expression of VEGF and NF- ΚB/P65 was greater in TC and UTC, and documented their significant positive correlations with the clinical stage and lymph node metastasis in TC. In addition there was a significant positive relationship between their expression, suggesting that they have important roles in TC and that they may be potential targets for gene therapy in TC patients. 关键词：甲状腺癌基因表达血管内皮生长因子 NF-ΚB

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Significance of VEGF and NF-κB Expression in Thyroid Carcinoma

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