预防性激光治疗单侧年龄相关性黄斑病变促进脉络膜新生血管形成:玻璃膜疣激光研究的最终结果

查看全文 作　　者：Owens [1]S.L.;Bunce C.;Brannon A.J.;潘佳鸿 机构地区：[1]Professorial Unit, Moorfields Eye Hospital, City Road, London EC1V2PD,UnitedKingdom Dr. 出　　处：《世界核心医学期刊文摘(眼科学分册)》索引2006年第2卷第5期,共1页 摘　　要：PURPOSE: The Drusen Laser Study evaluated macular laser to prevent choroidal neovascularization (CNV) and vision loss in high-risk age-related maculopathy (ARM). DESIGN: Prospective, interventional, randomized, controlled clinical trial in five hospital centers. METHODS: Patients in the unilateral group had neovascular ARM and drusen in the study eye. Study eyes were randomized to laser-treated or no-laser groups. For patients in the bilateral drusen group, eyes were randomized to right eye, laser or no laser; and left eye, alternative. Laser treatment comprised 12 argon spots. Outcome was best-corrected visual acuity and CNV signs, which were monitored for 3 years. RESULTS: In the unilateral group, vision loss occurred in 21 (28.8%) of 73 patients in laser vs 13 (19.7%) of 66 no-laser patients (P=.214). Incidence of CNV was 27 (29.7%) of 91 in laser vs 15 (17.65%) of 85 no-laser patients (P=.061). CNV onset was approximately 6 months earlier in laser-treated compared with no-laser patients (P=.05). In the bilateral group, vision loss occurred in six (8.3%)-of 72 laser-treated vs 10 (13.9%) of 72 fellow eyes (P=.3877). CNV incidence was 12 (11.6%) of 103 in laser-treated vs seven (6.8%) of 103 fellow eyes (P=.225). There was no difference in onset of CNV. CONCLUSIONS: Results do not support prophylactic laser of the fello weye of patients with neovascular ARM. Its role in patients with bilateral drusen remains unclear. 关 键 词：预防性激光治疗 年龄相关性黄斑病变 脉络膜新生血管 新生血管形成 玻璃膜疣 单侧 治疗组 视力丧失 医疗中心 临床试验