18F-氟脱氧葡萄糖的摄取作为原发性宫颈癌放疗后的预后指标

查看全文 作　　者：Dehdashti F.;P.W. [1]Grigsby;李奎 机构地区：[1]Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4921 Parkview Place, St. Louis, MO 63110, United States 出　　处：《世界核心医学期刊文摘(妇产科学分册)》索引2006年第2卷第9期,共1页 摘　　要：Purpose. We evaluated the prognostic significance of tumor metabolic activity on pretreatment positron emission tomography using the glucose analog F- 18 fluorodeoxyglucose (FDG- PET) in patients with carcinoma of the cervix undergoing radiotherapy with or without concurrent chemotherapy. Methods. We studied 96 consecutive patients who underwent FDG- PET prior to initiation of radiotherapy with or without concurrent chemotherapy for carcinoma of the cervix. Pretreatment FDG uptake of the primary tumor was assessed with the semiquantitative standardized uptake value (SUV) and correlated with di-sease- free and overall survival. Survival was estimated by the Kaplan- Meier method. Univariate and multivariate analyses were performed with the logistic likelihood ratio test and the Cox proportional hazards model, respectively. Results. Five-year disease- free survivals in patients with maximal SUV < 10.2 and ≥ 10.2 were 71% and 52% (P = 0.0289)- respectively, while overall survivals were 72% and 69% (P = 0.4), respectively. On multivariate analysis, lymph node metastasis on FDG- PET was found to be predictive of disease- free survival (P < 0.0001). Both the SUV for FDG and FIGO Stage I disease were found to be marginally predictive of disease- free survival (P = 0.055 and P = 0.058, respectively). Conclusions. FDG uptake within primary cervical cancer, as measured by SUV, is predictive of disease- free survival in patients undergoing radiotherapy for cervical cancer. High FDG uptake may be useful in identifying patients who may require more aggressive initial therapy. 关 键 词：氟脱氧葡萄糖 标准摄取值 预后指标 宫颈癌 放疗后 原发性 正电子发射计算机断层扫描 Cox比例风险模型