H pylori and gastric cancer: Shifting the global burden

查看全文 作　　者：Christian [1]Prinz;Susanne [1]Schwendy;Petra [1]Voland

机构地区：[1]II. MedicalDepartment, Technical University of Munich, D-81675 Munich,Germany

出　　处：《World Journal of Gastroenterology》索引2006年第12卷第34期,共7页

基　　金：Supported by Deutsche Forschungsgemeinschaft (DFGGraduiertenkolleg 333: Biology of Human Diseases) and by agrant from the DFG to C.P. (Pr 411/9-1) and the Dr. Else Kr nerFresenius Stiftung 摘　　要：Infection with H pylori leads to a persistent chronic in?ammation of the gastric mucosa, thereby increasing the risk of distal gastric adenocarcinoma. Numerous studies have determined a clear correlation between H pylori infection and the risk of gastric cancer; however, general eradication is not recommended as cancer prophylaxis and time points for treatment remain controversial in different areas of the world. Prevalence rates in Western countries are decreasing, especially in younger people (< 10%); and a decline in distal gastric adenocarcinoma has been observed. Risk groups in Western countries still show considerably higher risk of developing cancer, especially in patients infected with cagA + strains and in persons harboring genetic polymorphism of the IL-1B promoter (-511T/T) and the corresponding IL-1 receptor antagonist (IL-1RN*2). Thus, general eradication of all infected persons in Western countries not recommended and is limited to risk groups in order to achieve a risk reduction. In contrast, infection rates and cancer prevalence are still high in East Asian countries. A prevention strategy to treat infected persons may avoid the development of gastric cancer to a large extent and with enormous clinical importance. However, studies in China and Japan indicate that prevention of gastric cancer is effective only in those patients that do not display severe histological changes such as atrophy and intestinal metaplasia. Thus, prophylactic strategies to prevent gastric cancer in high risk populations such as China should therefore especially aim at individuals now at younger age when the histological alterations caused by the bacterial infection was still reversible. In countries with a low prevalence of gastric cancer, risk groups carrying cagA+ strains and IL-1 genetic polymorphisms should be identi?ed and treated. 关键词：幽门螺杆菌胃癌细菌感染治疗

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H pylori and gastric cancer: Shifting the global burden

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