Effect of Selenium Supplementation on Activity and mRNA Expression of Type 1 Deiodinase in Mice With Excessive Iodine Intake

查看全文 作　　者：XUE-FENG YANG XIAO-HUI HOU JIAN XW HUAI-LAN GUO CHEN-JIANG YING XIAO-YI CHEN XIU-FA [1]SUN

机构地区：[1]Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China

出　　处：《Biomedical and Environmental Sciences》索引2006年第19卷第4期,共7页

基　　金：This work was supported by the National Science Foundation of China (NSFC) (No. 30230330). 摘　　要：Objective To investigate the effect of selenium supplementation on the selenium status and selenoenzyme, especially the activity and mRNA expression of type 1 deiodinase (D1) in mice with excessive iodine (EI) intake and to explore the mechanism of selenium intervention on iodine-induced abnormities. Methods Weanling female BALB/c mice were given tap water or 3 mg/L of iodine or supplemented with 0.5 mg/L or 1.0 mg/L of selenium in the presence of excessive iodine for 5 months. Selenium status, thyroid hormone level, hepatic and renal D1 activity and mRNA expression were examined. Results Excessive iodine intake significantly decreased the selenium concentration in urine and liver, and the activity of glutathione peroxidase (GSH-Px) in liver. Meanwhile, serum total T4 (TT4) increased while serum total T3 (TT3) decreased. Hepatic D1 enzyme activity and mRNA expression were reduced by 33% and 86%, respectively. Renal D1 enzyme activity and mRNA were reduced by 30% and 55%, respectively. Selenium supplementation obviously increased selenium concentration, activity of GSH-Px and D1 as well as mRNA expression of D1. However, increasing the supplementation of Se from 0.5 to 1.0 mg/L did not further increase selenoenzyme activity and expression. Conclusion Relative selenium deficiency caused by excessive iodine plays an essential role in the mechanism of iodine-induced abnormalities. An appropriate dose of selenium supplementation exercises a beneficial intervention. 关键词：基因表达脱碘作用谷胱甘肽碘元素

相关文献

参考文献（30）
引证文献（7）
耦合文献（8）

参考文献(30)

引证文献(7)

耦合文献(8)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Effect of Selenium Supplementation on Activity and mRNA Expression of Type 1 Deiodinase in Mice With Excessive Iodine Intake

参考文献(30)

引证文献(7)

耦合文献(8)

用户提示