Celiac disease

查看全文 作　　者：Luis [1]Rodrigo

机构地区：[1]Gastroenterology Service,University Hospital Central Asturias,Oviedo,Spain

出　　处：《World Journal of Gastroenterology》索引2006年第12卷第41期,共9页

摘　　要：Celiac disease (CD) is a common autoimmune disorder,induced by the intake of gluten proteins present inwheat, barley and rye. Contrary to common belief,this disorder is a protean systemic disease, ratherthan merely a pure digestive alteration. CD is closelyassociated with genes that code HLA-II antigens, mainlyof DQ2 and DQ8 classes. Previously, it was considered tobe a rare childhood disorder, but is actually considereda frequent condition, present at any age, which mayhave multiple complications. Tissue transglutaminase-2(tTG), appears to be an important component of thisdisease, both, in its pathogenesis and diagnosis. ActiveCD is characterized by intestinal and/or extra-intestinalsymptoms, villous atrophy and crypt hyperplasia, andstrongly positive tTG auto-antibodies. The duodenalbiopsy is considered to be the “gold standard” fordiagnosis, but its practice has significant limitations inits interpretation, especially in adults. Occasionally, itresults in a false-negative because of patchy mucosalchanges and the presence of mucosal villous atrophyis often more severe in the proximal jejunum, usuallynot reached by endoscopic biopsies. CD is associatedwith increased rates of several diseases, such as irondef iciency anemia, osteoporosis, dermatitis herpetiformis,several neurologic and endocrine diseases, persistentchronic hypertransami-nasemia of unknown origin,various types of cancer and other autoimmune disorders.Treatment of CD dictates a strict, life-long gluten-freediet, which results in remission for most individuals,although its effect on some associated extraintestinalmanifestations remains to be established. 关键词：病理治疗腹腔疾病转谷氨酰胺酶

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Celiac disease

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