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Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by α-lipoic acid in humans

查看全文 作　　者：Fritz [1]Dünschede;Kirsten [1]Erbes;Achim [1]Kircher;Stefanie [1]Westermann;Joachim [1]Seifert;Arno [2]Schad;Kempski [3]Oliver;Alexandra K [4]Kiemer;Junginger [1]Theodor 高影响力作者 机构地区：[1]Department of General and Abdominal Surgery, University hospital Mainz, Germany;[2]Institute for Pathology, University hospital Mainz, Germany;[3]Institute for Neurosurgical Pathophysiology, University hospital Mainz, Germany;[4]Department of Pharmacy, Pharmaceutical Biology, Saarland University, Germany高影响力机构 出　　处：《World Journal of Gastroenterology》索引2006年第12卷第42期,共6页高影响力期刊 摘　　要：AIM: To evaluate the protective effects of precondition- ing by α-lipoic acid (LA) in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS: Twenty-four patients undergoing liver re- section for various reasons either received 600 mg LA or NaCl 15 min before transection performed under inflow occlusion of the liver. Blood samples and liver wedge bi- opsy samples were obtained after opening of the abdo- men immediately after inflow occlusion of the liver, and 30 min after the end of inflow occlusion of the liver. RESULTS: Serum levels of aspartate transferase and alanine transferase were reduced at all time points in patients who received LA in comparison to those who received NaCL. This was accompanied by reduced histo- morphological features of oncosis. We observed TUNEL- positive hepatocytes in the livers of the untreated patients, especially after 30 min of ischemia. LA attenu- ated this increase of TUNEL-positive hepatocytes. Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion. CONCLUSION: This is the first report on the poten- tial for LA reducing ischemia/reperfusion injury (IRI) of the liver in humans who were undergoing liver surgery. Beside its simple and rapid application, side effects did not occur. LA might therefore represent a new strategy against hepatic IRI in humans. 关 键 词：缺血灌注损伤 肝切除术 药理学 肝疾病
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