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Relationship between the severity of hepatitis C virus-related liver disease and the presence of Helicobacter species in the liver: A prospective study

查看全文 作　　者：Laurent [1,2]Castéra;Anne [3]Pedeboscq;Marcia [3]Rocha;Brigitte Le [4,5]Bail;Corinne [3]Asencio;Victor de [2]Lédinghen;Pierre-Henri [1]Bernard;Christophe [6]Laurent;Marie-Edith [7]Lafon;Maylis [6]Capdepont;Patrice [2]Couzigou;Paulette Bioulac-[4,5]Sage;Charles [1]Balabaud;[3]FrancisMégraud;Armelle [3]Ménard 高影响力作者 机构地区：[1]Service d'Hépato-Gastroentérologie, H?pital St-André, Bordeaux, France;[2]Service d'Hépato-Gastroentérologie, H?pital Haut Lévêque, Pessac, France;[3]INSERM, ERI 10, Laboratoire deBactériologie, Université Victor Segalen Bordeaux 2, BordeauxFrance;[4]INSERM E0362Groupe de Recherche pour l'étude du Foie, Université VictorSegalen Bordeaux 2, Bordeaux, France;[5]Service d'Anatomie Pathologique, H?pital Pellegrin, Bordeaux, France;[6]Service de ChirurgieDigestive, H?pital St-André, Bordeaux, France;[7]Laboratoire de Virologie, Université VictorSegalen Bordeaux 2, Bordeaux, France高影响力机构 出　　处：《World Journal of Gastroenterology》索引2006年第12卷第45期,共7页高影响力期刊 摘　　要：AIM: To determine the presence of Helicobacter species DNA in the liver of chronic hepatitis C (CHC) patients with and without cirrhosis as compared to controls, and to identify the bacterial species involved. METHODS: Seventy-nine consecutive patients (HBV and HIV negative) with a liver sample obtained after liver biopsy or hepatic resection were studied: 41 with CHC without cirrhosis, 12 with CHC and cirrhosis, and 26 controls (HCV negative). Polymerase chain reactions (PCRs) targeting Helicobacter 16S rDNA and species- specific were performed on DNA extracted from the liver. A gastric infection with H pylori was determined by serology and confirmed by 13C-urea breath test. RESULTS: Overall, Helicobacter 16S rDNA was found in 16 patients (20.2%). Although positive cases tended to be higher in CHC patients with cirrhosis (41.6%) than in those without cirrhosis (17.0%) or in controls (15.4%), the difference was not statistically significant (P =0.08). H pylori-like DNA was identified in 12 cases and H. pullorum DNA in 2, while 2 cases remained unidenti- fied. Gastric infection with H pylori was found in only 2 of these patients. CONCLUSION: Our results do not confirm the associ- ation of Helicobacter species DNA in the liver of CHC patients with advanced liver disease. The lack of correlation between positive H pylori serology and the presence of H pylori-like DNA in the liver may indicate the presence of a variant of this species. 关 键 词：肝炎 病毒 肝硬化 细菌
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